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10.3389/fimmu.2021.650331 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.650331 33777047!7988091!33777047     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 650331 Nephropedia Template TP {{tp|p=33777047|t=2021. Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody |pdf=|usr=}}{{33777047}} gab.com Text Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33777047 #FOAvip Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as a driver of the hyperinflammatory response seen in COVID-19. However, our understanding of the specific immune responses to SARS-CoV-2 remains limited. Mast cells (MCs) and eosinophils are innate immune cells that play pathogenic roles in many inflammatory responses. Here we report MC-derived proteases and eosinophil-associated mediators are elevated in COVID-19 patient sera and lung tissues. Stimulation of viral-sensing toll-like receptors in vitro and administration of synthetic viral RNA in vivo induced features of hyperinflammation, including cytokine elevation, immune cell airway infiltration, and MC-protease production-effects suppressed by an anti-Siglec-8 monoclonal antibody which selectively inhibits MCs and depletes eosinophils. Similarly, anti-Siglec-8 treatment reduced disease severity and airway inflammation in a respiratory viral infection model. These results suggest that MC and eosinophil activation are associated with COVID-19 inflammation and anti-Siglec-8 antibodies are a potential therapeutic approach for attenuating excessive inflammation during viral infections. Twit Text FOAVip Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33777047 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33777047 #FOAvip English Wikipedia <ref>{{Cite pmid|33777047}}</ref> Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody #MMPMID33777047 Gebremeskel S; Schanin J; Coyle KM; Butuci M; Luu T; Brock EC; Xu A; Wong A; Leung J; Korver W; Morin RD; Schleimer RP; Bochner BS; Youngblood BA Front Immunol 2021[]; 12 (ä): 650331 PMID33777047show ga Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as a driver of the hyperinflammatory response seen in COVID-19. However, our understanding of the specific immune responses to SARS-CoV-2 remains limited. Mast cells (MCs) and eosinophils are innate immune cells that play pathogenic roles in many inflammatory responses. Here we report MC-derived proteases and eosinophil-associated mediators are elevated in COVID-19 patient sera and lung tissues. Stimulation of viral-sensing toll-like receptors in vitro and administration of synthetic viral RNA in vivo induced features of hyperinflammation, including cytokine elevation, immune cell airway infiltration, and MC-protease production-effects suppressed by an anti-Siglec-8 monoclonal antibody which selectively inhibits MCs and depletes eosinophils. Similarly, anti-Siglec-8 treatment reduced disease severity and airway inflammation in a respiratory viral infection model. These results suggest that MC and eosinophil activation are associated with COVID-19 inflammation and anti-Siglec-8 antibodies are a potential therapeutic approach for attenuating excessive inflammation during viral infections. |Animals[MESH] |Antibodies, Monoclonal/pharmacology[MESH] |Antigens, CD/genetics/*immunology/metabolism[MESH] |Antigens, Differentiation, B-Lymphocyte/genetics/*immunology/metabolism[MESH] |COVID-19/*immunology/metabolism/prevention & control/virology[MESH] |Case-Control Studies[MESH] |Cytokines/metabolism[MESH] |Disease Models, Animal[MESH] |Eosinophils/drug effects/*immunology/metabolism/virology[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Lectins/antagonists & inhibitors/genetics/*immunology/metabolism[MESH] |Mast Cells/drug effects/*immunology/metabolism/virology[MESH] |Mice, Transgenic[MESH] |Peptide Hydrolases/metabolism[MESH] |Respiratory Syncytial Virus Infections/*immunology/metabolism/prevention & control/virology[MESH] |Respiratory Syncytial Viruses/*immunology[MESH] |SARS-CoV-2/*immunology[MESH]Mast Cell and Eosinophil Activation Are Associated With COVID-19 and T(epmc).pdf DeepDyve Pubget Overpricing