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10.3389/fimmu.2021.645013

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.645013
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33777042!7994612!33777042
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suck abstract from ncbi


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pmid33777042      Front+Immunol 2021 ; 12 (ä): 645013
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  • Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review #MMPMID33777042
  • Tang KT; Hsu BC; Chen DY
  • Front Immunol 2021[]; 12 (ä): 645013 PMID33777042show ga
  • Background: Numerous cases of the coronavirus disease 2019 (COVID-19) with autoimmune and rheumatic manifestations have been reported. Despite the available reviews that summarized its autoimmune/rheumatic manifestations, a systematic approach is still lacking. Therefore, we conducted a comprehensive systematic review in order to give an overview upon these rare but clinically significant manifestations. Methods: We performed a literature search of PubMed and EMBASE as of October 9, 2020. All articles relevant to either systemic or organ-specific autoimmune and rheumatic manifestations potentially associated with COVID-19 were collected. The reviewed literature were limited to adults >/=18 years. Results: Although most of the existing evidence was based on case reports or case series without a long-term follow-up, a variety of autoimmune/rheumatic manifestations were associated with COVID-19. The manifestations that have a consistent association with COVID-19 include autoimmune cytopenia, cutaneous vasculitis, encephalitis, and Guillain-Barre syndrome. Such association is conflicting as regards to antiphospholipid syndrome, hemophagocytic lymphohistiocytosis, and myasthenia gravis. Conclusion: Our systematic review indicated the potential of the COVID-19 virus to trigger a myriad of autoimmune and rheumatic manifestations, which should be considered amid global efforts to combat COVID-19.
  • |*Autoimmunity[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Autoimmune Diseases/diagnosis/epidemiology/*immunology[MESH]
  • |COVID-19/diagnosis/epidemiology/*immunology/virology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Rheumatic Diseases/diagnosis/epidemiology/*immunology/virology[MESH]
  • |SARS-CoV-2/*immunology/pathogenicity[MESH]


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