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10.1155/2021/6637227 http://scihub22266oqcxt.onion/10.1155/2021/6637227 33776574!7955656!33776574     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mediators+Inflamm 2021 ; 2021 (ä): 6637227 Nephropedia Template TP {{tp|p=33776574|t=2021. Corticosteroid Pulses for Hospitalized Patients with COVID-19: Effects on Mortality |pdf=|usr=}}{{33776574}} gab.com Text Corticosteroid Pulses for Hospitalized Patients with COVID-19: Effects on Mortality JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=33776574 #FOAvip OBJECTIVES: To assess the influence of corticosteroid pulses on 60-day mortality in hospitalized patients with severe COVID-19. METHODS: We designed a multicenter retrospective cohort study in three teaching hospitals of Castilla y Leon, Spain (865,096 people). We selected patients with confirmed COVID-19 and lung involvement with a pO2/FiO2<300, excluding those exposed to immunosuppressors before or during hospitalization, patients terminally ill at admission, or those who died in the first 24 hours. We performed a propensity score matching (PSM) adjusting covariates that modify the probability of being treated. Then, we used a Cox regression model in the PSM group to consider factors affecting mortality. RESULTS: From 2933 patients, 257 fulfilled the inclusion and exclusion criteria. 124 patients were on corticosteroid pulses (250 mg of methylprednisolone for three days), and 133 were not. 30.3% (37/122) of patients died in the corticosteroid pulse group and 42.9% (57/133) in the nonexposed cohort. These differences (12.6%, 95% CI [8.54-16.65]) were statically significant (log-rank 4.72, p = 0, 03). We performed PSM using the exact method. Mortality differences remained in the PSM group (log-rank 5.31, p = 0.021) and were still significant after a Cox regression model (HR for corticosteroid pulses 0.561; p = 0.039). CONCLUSIONS: This study provides evidence about treatment with corticosteroid pulses in severe COVID-19 that might significantly reduce mortality. Strict inclusion and exclusion criteria with that selection process set a reliable frame to compare mortality in both the exposed and nonexposed groups. Twit Text FOAVip Corticosteroid Pulses for Hospitalized Patients with COVID-19: Effects on Mortality ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=33776574 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33776574 #FOAvip English Wikipedia <ref>{{Cite pmid|33776574}}</ref> Corticosteroid Pulses for Hospitalized Patients with COVID-19: Effects on Mortality #MMPMID33776574 Cusacovich I; Aparisi A; Marcos M; Ybarra-Falcon C; Iglesias-Echevarria C; Lopez-Veloso M; Barraza-Vengoechea J; Duenas C; Juarros Martinez SA; Rodriguez-Alonso B; Martin-Oterino JA; Montero-Baladia M; Moralejo L; Andaluz-Ojeda D; Gonzalez-Fuentes R Mediators Inflamm 2021[]; 2021 (ä): 6637227 PMID33776574show ga OBJECTIVES: To assess the influence of corticosteroid pulses on 60-day mortality in hospitalized patients with severe COVID-19. METHODS: We designed a multicenter retrospective cohort study in three teaching hospitals of Castilla y Leon, Spain (865,096 people). We selected patients with confirmed COVID-19 and lung involvement with a pO2/FiO2<300, excluding those exposed to immunosuppressors before or during hospitalization, patients terminally ill at admission, or those who died in the first 24 hours. We performed a propensity score matching (PSM) adjusting covariates that modify the probability of being treated. Then, we used a Cox regression model in the PSM group to consider factors affecting mortality. RESULTS: From 2933 patients, 257 fulfilled the inclusion and exclusion criteria. 124 patients were on corticosteroid pulses (250 mg of methylprednisolone for three days), and 133 were not. 30.3% (37/122) of patients died in the corticosteroid pulse group and 42.9% (57/133) in the nonexposed cohort. These differences (12.6%, 95% CI [8.54-16.65]) were statically significant (log-rank 4.72, p = 0, 03). We performed PSM using the exact method. Mortality differences remained in the PSM group (log-rank 5.31, p = 0.021) and were still significant after a Cox regression model (HR for corticosteroid pulses 0.561; p = 0.039). CONCLUSIONS: This study provides evidence about treatment with corticosteroid pulses in severe COVID-19 that might significantly reduce mortality. Strict inclusion and exclusion criteria with that selection process set a reliable frame to compare mortality in both the exposed and nonexposed groups. |*COVID-19 Drug Treatment[MESH] |*Hospitalization[MESH] |Adrenal Cortex Hormones/*therapeutic use[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*mortality[MESH] |Female[MESH] |Humans[MESH] |Immunosuppressive Agents/therapeutic use[MESH] |Inpatients[MESH] |Male[MESH] |Middle Aged[MESH] |Propensity Score[MESH] |Proportional Hazards Models[MESH] |Retrospective Studies[MESH] |Spain/epidemiology[MESH]Corticosteroid Pulses for Hospitalized Patients with COVID-19: Effects(epmc).pdf DeepDyve Pubget Overpricing