Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.drudis.2021.03.013 http://scihub22266oqcxt.onion/10.1016/j.drudis.2021.03.013 33775925!7997138!33775925     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33775925&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Discov+Today 2021 ; 26 (8): 2036-2044 Nephropedia Template TP {{tp|p=33775925|t=2021. Diabetes, inflammation, and the adiponectin paradox: Therapeutic targets in SARS-CoV-2 |pdf=|usr=}}{{33775925}} gab.com Text Diabetes, inflammation, and the adiponectin paradox: Therapeutic targets in SARS-CoV-2 JO: Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=33775925 #FOAvip Aging and pre-existing conditions in older patients increase severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severity and its complications, although the causes remain unclear. Apart from acute pulmonary syndrome, Coronavirus 2019 (COVID-19) can increasingly induce chronic conditions. Importantly, SARS-CoV-2 triggers de novo type 2 diabetes mellitus (T2DM) linked to age-associated cardiovascular disease (CVD), cancers, and neurodegeneration. Mechanistically, SARS-CoV-2 induces inflammation, possibly through damage-associated molecular pattern (DAMP) signaling and 'cytokine storm,' causing insulin resistance and the adiponectin (APN) paradox, a phenomenon linking metabolic dysfunction to chronic disease. Accordingly, preventing the APN paradox by suppressing APN-related inflammatory signaling might prove beneficial. A better understanding could uncover novel therapies for SARS-CoV-2 and its chronic disorders. Twit Text FOAVip Diabetes, inflammation, and the adiponectin paradox: Therapeutic targets in SARS-CoV-2 ????Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=33775925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33775925 #FOAvip English Wikipedia <ref>{{Cite pmid|33775925}}</ref> Diabetes, inflammation, and the adiponectin paradox: Therapeutic targets in SARS-CoV-2 #MMPMID33775925 Ho G; Ali A; Takamatsu Y; Wada R; Masliah E; Hashimoto M Drug Discov Today 2021[Aug]; 26 (8): 2036-2044 PMID33775925show ga Aging and pre-existing conditions in older patients increase severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severity and its complications, although the causes remain unclear. Apart from acute pulmonary syndrome, Coronavirus 2019 (COVID-19) can increasingly induce chronic conditions. Importantly, SARS-CoV-2 triggers de novo type 2 diabetes mellitus (T2DM) linked to age-associated cardiovascular disease (CVD), cancers, and neurodegeneration. Mechanistically, SARS-CoV-2 induces inflammation, possibly through damage-associated molecular pattern (DAMP) signaling and 'cytokine storm,' causing insulin resistance and the adiponectin (APN) paradox, a phenomenon linking metabolic dysfunction to chronic disease. Accordingly, preventing the APN paradox by suppressing APN-related inflammatory signaling might prove beneficial. A better understanding could uncover novel therapies for SARS-CoV-2 and its chronic disorders. |*COVID-19/immunology/metabolism[MESH] |*SARS-CoV-2/pathogenicity/physiology[MESH] |Adiponectin/*metabolism[MESH] |Aging/*physiology[MESH] |Chronic Disease[MESH] |Diabetes Mellitus, Type 2/*immunology[MESH] |Humans[MESH] |Inflammation/*metabolism[MESH]Diabetes, inflammation, and the adiponectin paradox: Therapeutic targe(epmc).pdf DeepDyve Pubget Overpricing