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10.1016/j.jsbmb.2021.105883

http://scihub22266oqcxt.onion/10.1016/j.jsbmb.2021.105883
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suck abstract from ncbi


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pmid33775818      J+Steroid+Biochem+Mol+Biol 2021 ; 211 (ä): 105883
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  • Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies #MMPMID33775818
  • Petrelli F; Luciani A; Perego G; Dognini G; Colombelli PL; Ghidini A
  • J Steroid Biochem Mol Biol 2021[Jul]; 211 (ä): 105883 PMID33775818show ga
  • Vitamin D modulates the systemic inflammatory response through interaction with immune system. As such, it has a possible protective role against the risk of respiratory tract infections and other diseases. It may be useful in particular, during COVID-19 pandemic. PubMed, the Cochrane Library, and EMBASE were searched from inception until January 31, 2021, for observational or clinical studies reporting the prognosis (and therapeutic effect) of COVID-19 infection in patients with deficient vitamin D levels. The infection rate, severity, and death from COVID-19 infection were pooled to provide an odds ratio with a 95 % confidence interval (OR 95 % CI). An OR > 1 was associated with the worst outcome in deficient compared with nondeficient patients. We assessed the association between vitamin D and risk, severity, and mortality for COVID-19 infection, through a review of 43 observational studies. Among subjects with deficient vitamin D values, risk of COVID-19 infection was higher compared to those with replete values (OR = 1.26; 95 % CI, 1.19-1.34; P < .01). Vitamin D deficiency was also associated with worse severity and higher mortality than in nondeficient patients (OR = 2.6; 95 % CI, 1.84-3.67; P < .01 and OR = 1.22; 95 % CI, 1.04-1.43; P < .01, respectively). Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection. Supplementation may be considered as preventive and therapeutic measure.
  • |*Dietary Supplements[MESH]
  • |*Pandemics[MESH]
  • |COVID-19/blood/*epidemiology/mortality/prevention & control[MESH]
  • |Humans[MESH]
  • |Immunity, Innate/drug effects[MESH]
  • |Incidence[MESH]
  • |Observational Studies as Topic[MESH]
  • |Odds Ratio[MESH]
  • |Prognosis[MESH]
  • |Risk[MESH]
  • |SARS-CoV-2/*pathogenicity[MESH]
  • |Severity of Illness Index[MESH]
  • |Survival Analysis[MESH]
  • |Vitamin D Deficiency/blood/*epidemiology/mortality/prevention & control[MESH]


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