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10.1016/j.jclinepi.2021.03.020 http://scihub22266oqcxt.onion/10.1016/j.jclinepi.2021.03.020 33775812!7997163!33775812     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Epidemiol 2021 ; 136 (ä): 55-63 Nephropedia Template TP {{tp|p=33775812|t=2021. A metaresearch study revealed susceptibility of Covid-19 treatment research to white hat bias: first, do no harm |pdf=|usr=}}{{33775812}} gab.com Text A metaresearch study revealed susceptibility of Covid-19 treatment research to white hat bias: first, do no harm JO: J Clin Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=33775812 #FOAvip OBJECTIVE: To investigate the presence of white hat bias in Covid-19 treatment research by evaluating the effects of citation and reporting bias. STUDY DESIGN AND SETTING: Citation bias was investigated by assessing the degree of agreement between evidence provided by a remdesivir randomized controlled trial and its citing articles. The dissimilarity of outcomes derived from nonrandomized and randomized studies was tested by a meta-analysis of hydroxychloroquine effects on mortality. The differential influence of studies with beneficial over those with neutral results was evaluated by a bibliometric analysis. RESULTS: The articles citing the ACTT-1 remdesivir trial preferentially presented its positive outcomes in 55.83% and its negative outcomes in 6.43% of cases. The hydroxychloroquine indicated no significant effect by randomized studies, but a significant survival benefit by nonrandomized ones. Citation mapping revealed that the study reporting survival benefit from the hydroxychloroquine-azithromycin combination was the most influential, despite subsequent studies reporting potential harmful effects. CONCLUSION: The present study raises concerns about citation bias and a predilection of reporting beneficial over harmful effects in the Covid-19 treatment research, potentially in the context of white hat bias. Preregistration, data sharing and avoidance of selective reporting are crucial to ensure the credibility of future research. Twit Text FOAVip A metaresearch study revealed susceptibility of Covid-19 treatment research to white hat bias: first, do no harm ????J Clin Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=33775812 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33775812 #FOAvip English Wikipedia <ref>{{Cite pmid|33775812}}</ref> A metaresearch study revealed susceptibility of Covid-19 treatment research to white hat bias: first, do no harm #MMPMID33775812 Bellos I J Clin Epidemiol 2021[Aug]; 136 (ä): 55-63 PMID33775812show ga OBJECTIVE: To investigate the presence of white hat bias in Covid-19 treatment research by evaluating the effects of citation and reporting bias. STUDY DESIGN AND SETTING: Citation bias was investigated by assessing the degree of agreement between evidence provided by a remdesivir randomized controlled trial and its citing articles. The dissimilarity of outcomes derived from nonrandomized and randomized studies was tested by a meta-analysis of hydroxychloroquine effects on mortality. The differential influence of studies with beneficial over those with neutral results was evaluated by a bibliometric analysis. RESULTS: The articles citing the ACTT-1 remdesivir trial preferentially presented its positive outcomes in 55.83% and its negative outcomes in 6.43% of cases. The hydroxychloroquine indicated no significant effect by randomized studies, but a significant survival benefit by nonrandomized ones. Citation mapping revealed that the study reporting survival benefit from the hydroxychloroquine-azithromycin combination was the most influential, despite subsequent studies reporting potential harmful effects. CONCLUSION: The present study raises concerns about citation bias and a predilection of reporting beneficial over harmful effects in the Covid-19 treatment research, potentially in the context of white hat bias. Preregistration, data sharing and avoidance of selective reporting are crucial to ensure the credibility of future research. |*COVID-19 Drug Treatment[MESH] |Adenosine Monophosphate/*analogs & derivatives/therapeutic use[MESH] |Alanine/*analogs & derivatives/therapeutic use[MESH] |Anti-Bacterial Agents/*therapeutic use[MESH] |Antiviral Agents/*therapeutic use[MESH] |Azithromycin/*therapeutic use[MESH] |Bias[MESH] |Drug Therapy, Combination[MESH] |Humans[MESH] |Hydroxychloroquine/*therapeutic use[MESH]A metaresearch study revealed susceptibility of Covid-19 treatment res(epmc).pdf DeepDyve Pubget Overpricing