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10.1016/j.jmb.2021.166956 http://scihub22266oqcxt.onion/10.1016/j.jmb.2021.166956 33775667!7997149!33775667     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Biol 2021 ; 433 (10): 166956 Nephropedia Template TP {{tp|p=33775667|t=2021. Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection |pdf=|usr=}}{{33775667}} gab.com Text Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=33775667 #FOAvip The Covid-19 pandemic is a centenarial global catastrophe. Similar events are likely to be recurring with more frequency in the future. The inability to control the virus' impact is caused by many factors, but the lack of a technology infrastructure to detect and impede the virus at an early stage are principal shortcomings. Using phage display mutagenesis, we have generated a cohort of high performance antibody fragments (Fabs) that can be used in a sensitive point of care (POC) assay and are potent inhibitors (IC(50)-0.5 nM) to viral entry into cells. The POC assay is based on a split-enzyme (beta-lactamase) complementation strategy that detects virus particles at low nM levels. We have shown that this assay is equally effective for detecting other viruses like Ebola and Zika. Importantly, its components can be freeze dried and stored, but becomes fully active when rehydrated. Twit Text FOAVip Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=33775667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33775667 #FOAvip English Wikipedia <ref>{{Cite pmid|33775667}}</ref> Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection #MMPMID33775667 Slezak T; Kossiakoff AA J Mol Biol 2021[May]; 433 (10): 166956 PMID33775667show ga The Covid-19 pandemic is a centenarial global catastrophe. Similar events are likely to be recurring with more frequency in the future. The inability to control the virus' impact is caused by many factors, but the lack of a technology infrastructure to detect and impede the virus at an early stage are principal shortcomings. Using phage display mutagenesis, we have generated a cohort of high performance antibody fragments (Fabs) that can be used in a sensitive point of care (POC) assay and are potent inhibitors (IC(50)-0.5 nM) to viral entry into cells. The POC assay is based on a split-enzyme (beta-lactamase) complementation strategy that detects virus particles at low nM levels. We have shown that this assay is equally effective for detecting other viruses like Ebola and Zika. Importantly, its components can be freeze dried and stored, but becomes fully active when rehydrated. |*Antibody Affinity[MESH] |Amino Acid Sequence[MESH] |Animals[MESH] |Antibodies, Neutralizing/*chemistry/*immunology[MESH] |Chlorocebus aethiops[MESH] |Epitopes, B-Lymphocyte/chemistry/immunology[MESH] |Freeze Drying[MESH] |Genetic Complementation Test[MESH] |Immunoglobulin Fab Fragments/*chemistry/*immunology[MESH] |Neutralization Tests[MESH] |Peptide Library[MESH] |Point-of-Care Systems[MESH] |SARS-CoV-2/*immunology/*isolation & purification[MESH] |Spike Glycoprotein, Coronavirus/chemistry/immunology[MESH] |Vero Cells[MESH] |Virus Internalization[MESH]Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neu(epmc).pdf DeepDyve Pubget Overpricing