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10.1016/j.virol.2021.03.009 http://scihub22266oqcxt.onion/10.1016/j.virol.2021.03.009 33774551!7975276!33774551     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2021 ; 559 (ä): 1-9 Nephropedia Template TP {{tp|p=33774551|t=2021. The development and kinetics of functional antibody-dependent cell-mediated cytotoxicity (ADCC) to SARS-CoV-2 spike protein |pdf=|usr=}}{{33774551}} gab.com Text The development and kinetics of functional antibody-dependent cell-mediated cytotoxicity (ADCC) to SARS-CoV-2 spike protein JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=33774551 #FOAvip Since the COVID-19 pandemic, functional non-neutralizing antibody responses to SARS-CoV-2, including antibody-dependent cell-mediated cytotoxicity (ADCC), are poorly understood. We developed an ADCC assay utilizing a stably transfected, dual-reporter target cell line with inducible expression of a SARS-CoV-2 spike protein on the cell surface. Using this assay, we analyzed 61 convalescent serum samples from adults with PCR-confirmed COVID-19 and 15 samples from healthy uninfected controls. We found that 56 of 61 convalescent serum samples induced ADCC killing of SARS-CoV-2 S target cells, whereas none of the 15 healthy controls had detectable ADCC. We then found a modest decline in ADCC titer over a median 3-month follow-up in 21 patients who had serial samples available for analysis. We confirmed that the antibody-dependent target cell lysis was mediated primarily via the NK FcgammaRIIIa receptor (CD16). This ADCC assay had high sensitivity and specificity for detecting serologic immune responses to SARS-CoV-2. Twit Text FOAVip The development and kinetics of functional antibody-dependent cell-mediated cytotoxicity (ADCC) to SARS-CoV-2 spike protein ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=33774551 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33774551 #FOAvip English Wikipedia <ref>{{Cite pmid|33774551}}</ref> The development and kinetics of functional antibody-dependent cell-mediated cytotoxicity (ADCC) to SARS-CoV-2 spike protein #MMPMID33774551 Chen X; Rostad CA; Anderson LJ; Sun HY; Lapp SA; Stephens K; Hussaini L; Gibson T; Rouphael N; Anderson EJ Virology 2021[Jul]; 559 (ä): 1-9 PMID33774551show ga Since the COVID-19 pandemic, functional non-neutralizing antibody responses to SARS-CoV-2, including antibody-dependent cell-mediated cytotoxicity (ADCC), are poorly understood. We developed an ADCC assay utilizing a stably transfected, dual-reporter target cell line with inducible expression of a SARS-CoV-2 spike protein on the cell surface. Using this assay, we analyzed 61 convalescent serum samples from adults with PCR-confirmed COVID-19 and 15 samples from healthy uninfected controls. We found that 56 of 61 convalescent serum samples induced ADCC killing of SARS-CoV-2 S target cells, whereas none of the 15 healthy controls had detectable ADCC. We then found a modest decline in ADCC titer over a median 3-month follow-up in 21 patients who had serial samples available for analysis. We confirmed that the antibody-dependent target cell lysis was mediated primarily via the NK FcgammaRIIIa receptor (CD16). This ADCC assay had high sensitivity and specificity for detecting serologic immune responses to SARS-CoV-2. |*Antibody-Dependent Cell Cytotoxicity[MESH] |Adult[MESH] |Aged[MESH] |Antibodies, Neutralizing/blood/immunology[MESH] |Antibodies, Viral/blood/*immunology[MESH] |COVID-19/immunology[MESH] |Cell Line[MESH] |Cytotoxicity Tests, Immunologic[MESH] |Female[MESH] |Humans[MESH] |Killer Cells, Natural/immunology[MESH] |Kinetics[MESH] |Male[MESH] |Middle Aged[MESH] |Receptors, IgG/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Sensitivity and Specificity[MESH] |Spike Glycoprotein, Coronavirus/*immunology[MESH]The development and kinetics of functional antibody-dependent cell-med(epmc).pdf DeepDyve Pubget Overpricing