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10.1016/j.clim.2021.108716

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suck abstract from ncbi


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pmid33774179      Clin+Immunol 2021 ; 226 (ä): 108716
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  • Activation of classical and alternative complement pathways in the pathogenesis of lung injury in COVID-19 #MMPMID33774179
  • Satyam A; Tsokos MG; Brook OR; Hecht JL; Moulton VR; Tsokos GC
  • Clin Immunol 2021[May]; 226 (ä): 108716 PMID33774179show ga
  • Lung inflammation and damage is prominent in people infected with SARS-Cov-2 and a major determinant of morbidity and mortality. We report the deposition of complement components in the lungs of people who succumbed to COVID-19 consistent with the activation of the classical and the alternative pathways. Our study provides strong rationale for the expansion of trials involving the use of complement inhibitors to treat patients with COVID-19.
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/complications/*immunology[MESH]
  • |Complement Activation/*immunology[MESH]
  • |Complement Inactivating Agents/pharmacology/therapeutic use[MESH]
  • |Complement Pathway, Alternative/*immunology[MESH]
  • |Epithelial Cells/metabolism/pathology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunohistochemistry[MESH]
  • |Lung Injury/complications/*immunology/pathology/virology[MESH]
  • |Lung/diagnostic imaging/immunology/pathology[MESH]
  • |Male[MESH]


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