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10.1002/eji.202049101 http://scihub22266oqcxt.onion/10.1002/eji.202049101 33772767!8250065!33772767     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33772767&cmd=llinks): Failed to open stream: HTTP request failed! 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Peptide microarray-based analysis of antibody responses to SARS-CoV-2 identifies unique epitopes with potential for diagnostic test development |pdf=|usr=}}{{33772767}} gab.com Text Peptide microarray-based analysis of antibody responses to SARS-CoV-2 identifies unique epitopes with potential for diagnostic test development JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33772767 #FOAvip Humoral immunity to the Severe Adult Respiratory Syndrome (SARS) Coronavirus (CoV)-2 is not fully understood yet but is a crucial factor of immune protection. The possibility of antibody cross-reactivity between SARS-CoV-2 and other human coronaviruses (HCoVs) would have important implications for immune protection but also for the development of specific diagnostic ELISA tests. Using peptide microarrays, n = 24 patient samples and n = 12 control samples were screened for antibodies against the entire SARS-CoV-2 proteome as well as the Spike (S), Nucleocapsid (N), VME1 (V), R1ab, and Protein 3a (AP3A) of the HCoV strains SARS, MERS, OC43, and 229E. While widespread cross-reactivity was revealed across several immunodominant regions of S and N, IgG binding to several SARS-CoV-2-derived peptides provided statistically significant discrimination between COVID-19 patients and controls. Selected target peptides may serve as capture antigens for future, highly COVID-19-specific diagnostic antibody tests. Twit Text FOAVip Peptide microarray-based analysis of antibody responses to SARS-CoV-2 identifies unique epitopes with potential for diagnostic test development ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33772767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33772767 #FOAvip English Wikipedia <ref>{{Cite pmid|33772767}}</ref> Peptide microarray-based analysis of antibody responses to SARS-CoV-2 identifies unique epitopes with potential for diagnostic test development #MMPMID33772767 Holenya P; Lange PJ; Reimer U; Woltersdorf W; Panterodt T; Glas M; Wasner M; Eckey M; Drosch M; Hollidt JM; Naumann M; Kern F; Wenschuh H; Lange R; Schnatbaum K; Bier FF Eur J Immunol 2021[Jul]; 51 (7): 1839-1849 PMID33772767show ga Humoral immunity to the Severe Adult Respiratory Syndrome (SARS) Coronavirus (CoV)-2 is not fully understood yet but is a crucial factor of immune protection. The possibility of antibody cross-reactivity between SARS-CoV-2 and other human coronaviruses (HCoVs) would have important implications for immune protection but also for the development of specific diagnostic ELISA tests. Using peptide microarrays, n = 24 patient samples and n = 12 control samples were screened for antibodies against the entire SARS-CoV-2 proteome as well as the Spike (S), Nucleocapsid (N), VME1 (V), R1ab, and Protein 3a (AP3A) of the HCoV strains SARS, MERS, OC43, and 229E. While widespread cross-reactivity was revealed across several immunodominant regions of S and N, IgG binding to several SARS-CoV-2-derived peptides provided statistically significant discrimination between COVID-19 patients and controls. Selected target peptides may serve as capture antigens for future, highly COVID-19-specific diagnostic antibody tests. |Adult[MESH] |Aged[MESH] |Amino Acid Sequence/genetics[MESH] |Antibodies, Viral/*blood/immunology[MESH] |COVID-19/*diagnosis[MESH] |Coronavirus 229E, Human/immunology[MESH] |Coronavirus Nucleocapsid Proteins/immunology[MESH] |Coronavirus OC43, Human/immunology[MESH] |Cross Reactions/immunology[MESH] |Diagnostic Tests, Routine[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/blood/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Middle East Respiratory Syndrome Coronavirus/immunology[MESH] |Phosphoproteins/immunology[MESH] |Protein Array Analysis/*methods[MESH] |Proteome/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Severe acute respiratory syndrome-related coronavirus/immunology[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH] |Viral Proteins/*immunology[MESH]Peptide microarray-based analysis of antibody responses to SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing