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10.1093/ajhp/zxab133

http://scihub22266oqcxt.onion/10.1093/ajhp/zxab133
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33772262!ä!33772262

suck abstract from ncbi


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pmid33772262      Am+J+Health+Syst+Pharm 2021 ; 78 (13): 1195-1199
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  • Phentolamine continuous infusion in a pediatric patient with uncontrolled hypertension #MMPMID33772262
  • Hatt A
  • Am J Health Syst Pharm 2021[Jun]; 78 (13): 1195-1199 PMID33772262show ga
  • PURPOSE: A case of uncontrolled hypertension nonresponsive to traditional pharmacologic management in a pediatric patient with a ventricular assist device awaiting a heart transplant is reported. SUMMARY: A 4-month-old male in heart failure was experiencing uncontrolled hypertension. Because of a lack of hemodynamic stability, he was unable to be listed as a heart transplant candidate. He received multiple antihypertensive agents (calcium channel blockers, beta-blockers, and direct-acting vasodilators) as both intermittent and continuous infusions over the course of several days without achieving normotension. The decision was then made to administer intravenous phentolamine as a continuous infusion to pursue a different mechanism than with traditional antihypertensive agents to achieve hemodynamic stability. Within 8 hours of initiation of the continuous phentolamine infusion, the patient became normotensive and was listed for a heart transplant. The continuous phentolamine infusion was administered over the next 4 days to maintain normotension, and on day 4 the patient underwent successful orthotopic heart transplantation. CONCLUSION: A 4-month-old male in heart failure with a ventricular assist device, experiencing uncontrolled hypertension nonresponsive to traditional pharmacologic management, was successfully treated with a continuous intravenous infusion of phentolamine.
  • |*Heart Failure/drug therapy[MESH]
  • |*Heart Transplantation[MESH]
  • |*Heart-Assist Devices[MESH]
  • |*Hypertension/drug therapy[MESH]
  • |Child[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Phentolamine[MESH]


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