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10.1093/infdis/jiab163

http://scihub22266oqcxt.onion/10.1093/infdis/jiab163
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33770176!8083649!33770176
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suck abstract from ncbi


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pmid33770176      J+Infect+Dis 2021 ; 224 (10): 1631-1640
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  • Navigating the Uncertainties of COVID-19-Associated Aspergillosis: A Comparison With Influenza-Associated Aspergillosis #MMPMID33770176
  • Lamoth F; Lewis RE; Walsh TJ; Kontoyiannis DP
  • J Infect Dis 2021[Nov]; 224 (10): 1631-1640 PMID33770176show ga
  • Invasive pulmonary aspergillosis (IPA) is increasingly recognized as a life-threatening superinfection of severe respiratory viral infections, such as influenza. The pandemic of Coronavirus Disease 2019 (COVID-19) due to emerging SARS-CoV-2 rose concern about the eventuality of IPA complicating COVID-19 in intensive care unit patients. A variable incidence of such complication has been reported, which can be partly attributed to differences in diagnostic strategy and IPA definitions, and possibly local environmental/epidemiological factors. In this article, we discuss the similarities and differences between influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA). Compared to IAPA, the majority of CAPA cases have been classified as putative rather than proven/probable IPA. Distinct physiopathology of influenza and COVID-19 may explain these discrepancies. Whether CAPA represents a distinct entity is still debatable and many questions remain unanswered, such as its actual incidence, the predisposing role of corticosteroids or immunomodulatory drugs, and the indications for antifungal therapy.
  • |*Aspergillosis/complications/drug therapy[MESH]
  • |*COVID-19/complications[MESH]
  • |*Influenza, Human/complications/drug therapy[MESH]
  • |*Invasive Pulmonary Aspergillosis/complications/diagnosis/drug therapy[MESH]
  • |*Pulmonary Aspergillosis/complications/drug therapy[MESH]
  • |Antifungal Agents/therapeutic use[MESH]
  • |Humans[MESH]


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