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10.1038/s41598-021-86452-3

http://scihub22266oqcxt.onion/10.1038/s41598-021-86452-3
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suck abstract from ncbi


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pmid33767292      Sci+Rep 2021 ; 11 (1): 6928
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  • Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts #MMPMID33767292
  • Molteni E; Astley CM; Ma W; Sudre CH; Magee LA; Murray B; Fall T; Gomez MF; Tsereteli N; Franks PW; Brownstein JS; Davies R; Wolf J; Spector TD; Ourselin S; Steves CJ; Chan AT; Modat M
  • Sci Rep 2021[Mar]; 11 (1): 6928 PMID33767292show ga
  • We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18-44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |COVID-19/*complications/physiopathology/virology[MESH]
  • |Cohort Studies[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Mobile Applications[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Complications, Infectious/*physiopathology[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Severity of Illness Index[MESH]


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