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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 NPJ+Vaccines 2021 ; 6 (1): 44 Nephropedia Template TP
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The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization #MMPMID33767200
Zou J; Xie X; Fontes-Garfias CR; Swanson KA; Kanevsky I; Tompkins K; Cutler M; Cooper D; Dormitzer PR; Shi PY
NPJ Vaccines 2021[Mar]; 6 (1): 44 PMID33767200show ga
Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7-2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.