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10.1038/s41541-021-00313-8

http://scihub22266oqcxt.onion/10.1038/s41541-021-00313-8
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33767200!7994717!33767200
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suck abstract from ncbi


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pmid33767200      NPJ+Vaccines 2021 ; 6 (1): 44
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  • The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization #MMPMID33767200
  • Zou J; Xie X; Fontes-Garfias CR; Swanson KA; Kanevsky I; Tompkins K; Cutler M; Cooper D; Dormitzer PR; Shi PY
  • NPJ Vaccines 2021[Mar]; 6 (1): 44 PMID33767200show ga
  • Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7-2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
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