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10.1038/s41467-021-22132-0 http://scihub22266oqcxt.onion/10.1038/s41467-021-22132-0 33767178!7994808!33767178     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 1891 Nephropedia Template TP {{tp|p=33767178|t=2021. Combination therapy protects macaques against advanced Marburg virus disease |pdf=|usr=}}{{33767178}} gab.com Text Combination therapy protects macaques against advanced Marburg virus disease JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33767178 #FOAvip Monoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae), and more recently, SARS-CoV-2. One of the major challenges of acute viral infections is the treatment of advanced disease. Thus, extending the window of therapeutic intervention is critical. Here, we explore the benefit of combination therapy with a mAb and remdesivir in a non-human primate model of Marburg virus (MARV) disease. While rhesus monkeys are protected against lethal infection when treatment with either a human mAb (MR186-YTE; 100%), or remdesivir (80%), is initiated 5 days post-inoculation (dpi) with MARV, no animals survive when either treatment is initiated alone beginning 6 dpi. However, by combining MR186-YTE with remdesivir beginning 6 dpi, significant protection (80%) is achieved, thereby extending the therapeutic window. These results suggest value in exploring combination therapy in patients presenting with advanced filovirus disease. Twit Text FOAVip Combination therapy protects macaques against advanced Marburg virus disease ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33767178 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33767178 #FOAvip English Wikipedia <ref>{{Cite pmid|33767178}}</ref> Combination therapy protects macaques against advanced Marburg virus disease #MMPMID33767178 Cross RW; Bornholdt ZA; Prasad AN; Borisevich V; Agans KN; Deer DJ; Abelson DM; Kim DH; Shestowsky WS; Campbell LA; Bunyan E; Geisbert JB; Fenton KA; Zeitlin L; Porter DP; Geisbert TW Nat Commun 2021[Mar]; 12 (1): 1891 PMID33767178show ga Monoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae), and more recently, SARS-CoV-2. One of the major challenges of acute viral infections is the treatment of advanced disease. Thus, extending the window of therapeutic intervention is critical. Here, we explore the benefit of combination therapy with a mAb and remdesivir in a non-human primate model of Marburg virus (MARV) disease. While rhesus monkeys are protected against lethal infection when treatment with either a human mAb (MR186-YTE; 100%), or remdesivir (80%), is initiated 5 days post-inoculation (dpi) with MARV, no animals survive when either treatment is initiated alone beginning 6 dpi. However, by combining MR186-YTE with remdesivir beginning 6 dpi, significant protection (80%) is achieved, thereby extending the therapeutic window. These results suggest value in exploring combination therapy in patients presenting with advanced filovirus disease. |Adenosine Monophosphate/*analogs & derivatives/therapeutic use[MESH] |Alanine/*analogs & derivatives/therapeutic use[MESH] |Animals[MESH] |Antibodies, Monoclonal/*therapeutic use[MESH] |Antibodies, Viral/*therapeutic use[MESH] |Disease Models, Animal[MESH] |Drug Therapy, Combination[MESH] |Macaca mulatta[MESH] |Marburg Virus Disease/*drug therapy/prevention & control[MESH] |Marburgvirus/*drug effects[MESH]Combination therapy protects macaques against advanced Marburg virus d(epmc).pdf DeepDyve Pubget Overpricing