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10.1136/bcr-2020-236984

http://scihub22266oqcxt.onion/10.1136/bcr-2020-236984
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33766959!8006769!33766959
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suck abstract from ncbi


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pmid33766959      BMJ+Case+Rep 2021 ; 14 (3): ä
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  • Successful treatment of positive-sense RNA virus coinfection with autoimmune hepatitis using double filtration plasmapheresis #MMPMID33766959
  • Kamimura H; Kamimura K; Tsuchiya A; Terai S
  • BMJ Case Rep 2021[Mar]; 14 (3): ä PMID33766959show ga
  • Double filtration plasmapheresis (DFPP) is an apheretic technique that selectively removes high molecular weight substances using a plasma component filter. DFPP has been used to treat positive-sense RNA virus infections, mainly chronic hepatitis C virus (HCV) infection, because of its ability to directly eliminate viral particles from blood plasma from 2008 to about 2015, before direct-acting antiviral agents was marketed. This effect has been termed virus removal and eradication by DFPP. HCV is a positive-sense RNA virus similar to West Nile virus, dengue virus and the SARS and Middle East respiratory syndrome coronaviruses. SARS-CoV-2 is classified same viral species. These viruses are all classified in Family Flaviviridae which are family of single-stranded plus-stranded RNA viruses. Viral particles are 40-60 nm in diameter, enveloped and spherical in shape. We present a rare case of HCV removal where an RNA virus infection that copresented with virus-associated autoimmune hepatitis was eliminated using DFPP. Our results indicate that DFPP may facilitate prompt viraemia reduction and may have novel treatment applications for SARS-CoV-2, that is, use of therapeutic plasma exchange for fulminant COVID-19.
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19/complications/therapy[MESH]
  • |Coinfection/*therapy/*virology[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Female[MESH]
  • |Hepatitis C, Chronic/complications/*therapy[MESH]
  • |Hepatitis, Autoimmune/complications/*therapy[MESH]
  • |Humans[MESH]
  • |Interferon alpha-2/therapeutic use[MESH]
  • |Middle Aged[MESH]
  • |Plasmapheresis/*methods[MESH]
  • |Polyethylene Glycols/therapeutic use[MESH]
  • |Positive-Strand RNA Viruses/isolation & purification[MESH]
  • |Ribavirin/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]
  • |Treatment Outcome[MESH]


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