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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Science 2021 ; 372 (6549): 1413-8 Nephropedia Template TP
Stamatatos L; Czartoski J; Wan YH; Homad LJ; Rubin V; Glantz H; Neradilek M; Seydoux E; Jennewein MF; MacCamy AJ; Feng J; Mize G; De Rosa SC; Finzi A; Lemos MP; Cohen KW; Moodie Z; McElrath MJ; McGuire AT
Science 2021[Mar]; 372 (6549): 1413-8 PMID33766944show ga
Emerging SARS-CoV-2 variants have raised concerns about resistance to neutralizing antibodies elicited by previous infection or vaccination. We examined whether sera from recovered and naive donors collected prior to, and following immunizations with existing mRNA vaccines, could neutralize the Wuhan-Hu-1 and B.1.351 variants. Pre-vaccination sera from recovered donors neutralized Wuhan-Hu-1 and sporadically neutralized B.1.351, but a single immunization boosted neutralizing titers against all variants and SARS-CoV-1 by up to 1000-fold. Neutralization was due to antibodies targeting the receptor binding domain and was not boosted by a second immunization. Immunization of naive donors also elicited cross-neutralizing responses, but at lower titers. Our study highlights the importance of vaccinating both uninfected and previously infected persons to elicit cross-variant neutralizing antibodies.