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10.1016/j.jamcollsurg.2021.02.019

http://scihub22266oqcxt.onion/10.1016/j.jamcollsurg.2021.02.019
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33766727!7982779!33766727
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suck abstract from ncbi


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pmid33766727      J+Am+Coll+Surg 2021 ; 232 (6): 995-1003
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  • Fibrinolysis Shutdown in COVID-19: Clinical Manifestations, Molecular Mechanisms, and Therapeutic Implications #MMPMID33766727
  • Meizoso JP; Moore HB; Moore EE
  • J Am Coll Surg 2021[Jun]; 232 (6): 995-1003 PMID33766727show ga
  • The COVID-19 pandemic has introduced a global public health threat unparalleled in our history. The most severe cases are marked by ARDS attributed to microvascular thrombosis. Hypercoagulability, resulting in a profoundly prothrombotic state, is a distinct feature of COVID-19 and is accentuated by a high incidence of fibrinolysis shutdown. The aims of this review were to describe the manifestations of fibrinolysis shutdown in COVID-19 and its associated outcomes, review the molecular mechanisms of dysregulated fibrinolysis associated with COVID-19, and discuss potential implications and therapeutic targets for patients with severe COVID-19.
  • |*Fibrinolysis[MESH]
  • |Blood Coagulation Disorders/etiology/therapy/virology[MESH]
  • |COVID-19/blood/*complications[MESH]
  • |Humans[MESH]


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