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10.1016/j.gene.2021.145596 http://scihub22266oqcxt.onion/10.1016/j.gene.2021.145596 33766711!7985683!33766711     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33766711&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene 2021 ; 784 (ä): 145596 Nephropedia Template TP {{tp|p=33766711|t=2021. SARS-CoV-2 variants lacking ORF8 occurred in farmed mink and pangolin |pdf=|usr=}}{{33766711}} gab.com Text SARS-CoV-2 variants lacking ORF8 occurred in farmed mink and pangolin JO: Gene http://www.kidney.de/pget.php?&tw=1&pmid=33766711 #FOAvip The SARS-CoV-2 Variant of Concern 202012/01 (VOC-202012/01) is rapidly spreading worldwide owing to its substantial transmission advantage. The variant has changes in critical sites of the spike protein with potential biological significance. Moreover, VOC-202012/01 has a mutation that inactivates the ORF8 protein, whose absence can change the clinical features of the infection. Why VOC-202012/01 is more transmissible remains unclear, but spike mutations and ORF8 inactivation stand out by their known phenotypic effects. Here I show that variants combining relevant spike mutations and the absence of ORF8 occurred in SARS-CoV-2 and related viruses circulating in other host species. A truncated ORF8 (Q23stop) occurred in a SARS-CoV-2-related virus from a pangolin seized in China in 2017, also with several mutations in critical spike sites. Strikingly, I found that variants without ORF8 (E19stop) and with the N501T spike mutation circulated in farmed mink and humans from Denmark. Although with differences to VOC-202012/01, the identification of these variants highlights the danger of having reservoirs of SARS-CoV-2 and related viruses where more transmissible variants may occur and spill over to humans. Twit Text FOAVip SARS-CoV-2 variants lacking ORF8 occurred in farmed mink and pangolin ????Gene http://www.kidney.de/pget.php?&tw=1&pmid=33766711 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33766711 #FOAvip English Wikipedia <ref>{{Cite pmid|33766711}}</ref> SARS-CoV-2 variants lacking ORF8 occurred in farmed mink and pangolin #MMPMID33766711 Pereira F Gene 2021[Jun]; 784 (ä): 145596 PMID33766711show ga The SARS-CoV-2 Variant of Concern 202012/01 (VOC-202012/01) is rapidly spreading worldwide owing to its substantial transmission advantage. The variant has changes in critical sites of the spike protein with potential biological significance. Moreover, VOC-202012/01 has a mutation that inactivates the ORF8 protein, whose absence can change the clinical features of the infection. Why VOC-202012/01 is more transmissible remains unclear, but spike mutations and ORF8 inactivation stand out by their known phenotypic effects. Here I show that variants combining relevant spike mutations and the absence of ORF8 occurred in SARS-CoV-2 and related viruses circulating in other host species. A truncated ORF8 (Q23stop) occurred in a SARS-CoV-2-related virus from a pangolin seized in China in 2017, also with several mutations in critical spike sites. Strikingly, I found that variants without ORF8 (E19stop) and with the N501T spike mutation circulated in farmed mink and humans from Denmark. Although with differences to VOC-202012/01, the identification of these variants highlights the danger of having reservoirs of SARS-CoV-2 and related viruses where more transmissible variants may occur and spill over to humans. |Animals[MESH] |COVID-19/transmission/*veterinary/virology[MESH] |China[MESH] |Codon, Nonsense[MESH] |Denmark[MESH] |Disease Reservoirs/veterinary/virology[MESH] |Host Specificity[MESH] |Humans[MESH] |Mink/*virology[MESH] |Pangolins/*virology[MESH] |SARS-CoV-2/*genetics/isolation & purification[MESH] |Spike Glycoprotein, Coronavirus/*genetics[MESH]SARS-CoV-2 variants lacking ORF8 occurred in farmed mink and pangolin (epmc).pdf DeepDyve Pubget Overpricing