Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ijbiomac.2021.03.112 http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2021.03.112 33766591!7982646!33766591     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Macromol 2021 ; 181 (ä): 605-611 Nephropedia Template TP {{tp|p=33766591|t=2021. A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase |pdf=|usr=}}{{33766591}} gab.com Text A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase JO: Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=33766591 #FOAvip The outbreaks of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in 2019, have highlighted the concerns about the lack of potential vaccines or antivirals approved for inhibition of CoVs infection. SARS-CoV-2 RNA dependent RNA polymerase (RdRp) which is almost preserved across different viral species can be a potential target for development of antiviral drugs, including nucleoside analogues (NA). However, ExoN proofreading activity of CoVs leads to their protection from several NAs. Therefore, potential platforms based on the development of efficient NAs with broad-spectrum efficacy against human CoVs should be explored. This study was then aimed to present an overview on the development of NAs-based drug repurposing for targeting SARS-CoV-2 RdRp by computational analysis. Afterwards, the clinical development of some NAs including Favipiravir, Sofosbuvir, Ribavirin, Tenofovir, and Remdesivir as potential inhibitors of RdRp, were surveyed. Overall, exploring broad-spectrum NAs as promising inhibitors of RdRp may provide useful information about the identification of potential antiviral repurposed drugs against SARS-CoV-2. Twit Text FOAVip A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase ????Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=33766591 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33766591 #FOAvip English Wikipedia <ref>{{Cite pmid|33766591}}</ref> A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase #MMPMID33766591 Khan S; Attar F; Bloukh SH; Sharifi M; Nabi F; Bai Q; Khan RH; Falahati M Int J Biol Macromol 2021[Jun]; 181 (ä): 605-611 PMID33766591show ga The outbreaks of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in 2019, have highlighted the concerns about the lack of potential vaccines or antivirals approved for inhibition of CoVs infection. SARS-CoV-2 RNA dependent RNA polymerase (RdRp) which is almost preserved across different viral species can be a potential target for development of antiviral drugs, including nucleoside analogues (NA). However, ExoN proofreading activity of CoVs leads to their protection from several NAs. Therefore, potential platforms based on the development of efficient NAs with broad-spectrum efficacy against human CoVs should be explored. This study was then aimed to present an overview on the development of NAs-based drug repurposing for targeting SARS-CoV-2 RdRp by computational analysis. Afterwards, the clinical development of some NAs including Favipiravir, Sofosbuvir, Ribavirin, Tenofovir, and Remdesivir as potential inhibitors of RdRp, were surveyed. Overall, exploring broad-spectrum NAs as promising inhibitors of RdRp may provide useful information about the identification of potential antiviral repurposed drugs against SARS-CoV-2. |*COVID-19 Drug Treatment[MESH] |Adenosine Monophosphate/analogs & derivatives/pharmacology[MESH] |Alanine/analogs & derivatives/pharmacology[MESH] |Antiviral Agents/pharmacology[MESH] |COVID-19/virology[MESH] |Computational Biology/methods[MESH] |Drug Repositioning/methods[MESH] |Humans[MESH] |Models, Molecular[MESH] |Nucleosides/*pharmacology[MESH] |RNA-Dependent RNA Polymerase/antagonists & inhibitors/*metabolism[MESH]A review on the interaction of nucleoside analogues with SARS-CoV-2 RN(epmc).pdf DeepDyve Pubget Overpricing