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10.1177/17534666211007214

http://scihub22266oqcxt.onion/10.1177/17534666211007214
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suck abstract from ncbi


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pmid33765902      Ther+Adv+Respir+Dis 2021 ; 15 (ä): 17534666211007214
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  • Clinical effectiveness of drugs in hospitalized patients with COVID-19: a systematic review and meta-analysis #MMPMID33765902
  • Abeldano Zuniga RA; Coca SM; Abeldano GF; Gonzalez-Villoria RAM
  • Ther Adv Respir Dis 2021[Jan]; 15 (ä): 17534666211007214 PMID33765902show ga
  • The aim was to assess the clinical effectiveness of drugs used in hospitalized patients with COVID-19 infection. We conducted a systematic review of randomized clinical trials assessing treatment with remdesivir, chloroquine, hydroxychloroquine, lopinavir, ritonavir, dexamethasone, and convalescent plasma, for hospitalized patients with a diagnosis of SARS-CoV-2 infection. The outcomes were mortality, clinical improvement, duration of ventilation, duration of oxygen support, duration of hospitalization, virological clearance, and severe adverse events. A total of 48 studies were retrieved from the databases. Eleven articles were finally included in the data extraction and qualitative synthesis of results. The meta-analysis suggests a benefit of dexamethasone versus standard care in the reduction of risk of mortality at day 28; and the clinical improvement at days 14 and 28 in patients treated with remdesivir. We can conclude that dexamethasone would have a better result in hospitalized patients, especially in low-resources settings. The analysis of the main treatments proposed for hospitalized patients is of vital importance to reduce mortality in low-income countries, since the COVID-19 pandemic had an economic impact worldwide with the loss of jobs and economic decline in countries with scarce resources.The reviews of this paper are available via the supplemental material section.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Hospitalization[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Humans[MESH]


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