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10.1016/j.intimp.2021.107568 http://scihub22266oqcxt.onion/10.1016/j.intimp.2021.107568 33765612!7982796!33765612     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33765612&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2021 ; 95 (ä): 107568 Nephropedia Template TP {{tp|p=33765612|t=2021. ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19 |pdf=|usr=}}{{33765612}} gab.com Text ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19 JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33765612 #FOAvip Novel coronavirus disease (COVID-19) pandemic has become a global health emergency. It has been reported that a few conditions, including cancer, predispose individuals to SARS-CoV-2 infection and severe form of COVID-19. These findings led us to evaluate the susceptibility of colon adenocarcinoma (COAD) patients to SARS-CoV-2 infection by investigating ACE2 expression in their tumor tissues. The expression analysis revealed that both mRNA and protein levels of ACE2 had increased in colon cancer samples than normal group. Next, the prognosis analysis has indicated that the upregulation of ACE2 was not correlated with patient survival outcomes. Further assessment displayed the hypomethylation of the ACE2 gene promoter in COAD patients. This methylation status has a strong negative correlation with ACE2 gene expression. The functional enrichment analysis of the genes that had similar expression patterns with ACE2 in colon cancer tissues demonstrated that they mainly enriched in Vitamin digestion and absorption pathway. Finally, we found that ACE2 gene expression had a significant association with the immune cell infiltration levels in COAD patients. In conclusion, it has plausible that COAD patients are more likely to be infected with SARS-CoV-2 and experience severe injuries. Moreover, COVID-19 would bring unfavorable survival outcomes for patients with colon cancer by way of immune cell infiltration linked process. The present study highlights the importance of preventiveactionsfor COAD patients during the COVID-19 pandemic. Twit Text FOAVip ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19 ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33765612 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33765612 #FOAvip English Wikipedia <ref>{{Cite pmid|33765612}}</ref> ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19 #MMPMID33765612 Ahmadi M; Pashangzadeh S; Mousavi P; Saffarzadeh N; Amin Habibi M; Hajiesmaeili F; Rezaei N Int Immunopharmacol 2021[Jun]; 95 (ä): 107568 PMID33765612show ga Novel coronavirus disease (COVID-19) pandemic has become a global health emergency. It has been reported that a few conditions, including cancer, predispose individuals to SARS-CoV-2 infection and severe form of COVID-19. These findings led us to evaluate the susceptibility of colon adenocarcinoma (COAD) patients to SARS-CoV-2 infection by investigating ACE2 expression in their tumor tissues. The expression analysis revealed that both mRNA and protein levels of ACE2 had increased in colon cancer samples than normal group. Next, the prognosis analysis has indicated that the upregulation of ACE2 was not correlated with patient survival outcomes. Further assessment displayed the hypomethylation of the ACE2 gene promoter in COAD patients. This methylation status has a strong negative correlation with ACE2 gene expression. The functional enrichment analysis of the genes that had similar expression patterns with ACE2 in colon cancer tissues demonstrated that they mainly enriched in Vitamin digestion and absorption pathway. Finally, we found that ACE2 gene expression had a significant association with the immune cell infiltration levels in COAD patients. In conclusion, it has plausible that COAD patients are more likely to be infected with SARS-CoV-2 and experience severe injuries. Moreover, COVID-19 would bring unfavorable survival outcomes for patients with colon cancer by way of immune cell infiltration linked process. The present study highlights the importance of preventiveactionsfor COAD patients during the COVID-19 pandemic. |Adenocarcinoma/complications/*genetics/*immunology[MESH] |Angiotensin-Converting Enzyme 2/*genetics/*immunology[MESH] |COVID-19/*complications/diagnosis[MESH] |Colonic Neoplasms/complications/*genetics/*immunology[MESH] |DNA Methylation[MESH] |Databases, Genetic[MESH] |Gene Expression Regulation, Neoplastic/immunology[MESH] |Humans[MESH] |Lymphocytes, Tumor-Infiltrating[MESH] |Prognosis[MESH] |Survival Analysis[MESH]ACE2 correlates with immune infiltrates in colon adenocarcinoma: Impli(epmc).pdf DeepDyve Pubget Overpricing