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10.1016/j.immuni.2021.03.002 http://scihub22266oqcxt.onion/10.1016/j.immuni.2021.03.002 33765435!7988739!33765435     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33765435.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2021 ; 54 (4): 753-768.e5 Nephropedia Template TP {{tp|p=33765435|t=2021. Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses |pdf=|usr=}}{{33765435}} gab.com Text Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33765435 #FOAvip Viral infections induce a conserved host response distinct from bacterial infections. We hypothesized that the conserved response is associated with disease severity and is distinct between patients with different outcomes. To test this, we integrated 4,780 blood transcriptome profiles from patients aged 0 to 90 years infected with one of 16 viruses, including SARS-CoV-2, Ebola, chikungunya, and influenza, across 34 cohorts from 18 countries, and single-cell RNA sequencing profiles of 702,970 immune cells from 289 samples across three cohorts. Severe viral infection was associated with increased hematopoiesis, myelopoiesis, and myeloid-derived suppressor cells. We identified protective and detrimental gene modules that defined distinct trajectories associated with mild versus severe outcomes. The interferon response was decoupled from the protective host response in patients with severe outcomes. These findings were consistent, irrespective of age and virus, and provide insights to accelerate the development of diagnostics and host-directed therapies to improve global pandemic preparedness. Twit Text FOAVip Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33765435 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33765435 #FOAvip English Wikipedia <ref>{{Cite pmid|33765435}}</ref> Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses #MMPMID33765435 Zheng H; Rao AM; Dermadi D; Toh J; Murphy Jones L; Donato M; Liu Y; Su Y; Dai CL; Kornilov SA; Karagiannis M; Marantos T; Hasin-Brumshtein Y; He YD; Giamarellos-Bourboulis EJ; Heath JR; Khatri P Immunity 2021[Apr]; 54 (4): 753-768.e5 PMID33765435show ga Viral infections induce a conserved host response distinct from bacterial infections. We hypothesized that the conserved response is associated with disease severity and is distinct between patients with different outcomes. To test this, we integrated 4,780 blood transcriptome profiles from patients aged 0 to 90 years infected with one of 16 viruses, including SARS-CoV-2, Ebola, chikungunya, and influenza, across 34 cohorts from 18 countries, and single-cell RNA sequencing profiles of 702,970 immune cells from 289 samples across three cohorts. Severe viral infection was associated with increased hematopoiesis, myelopoiesis, and myeloid-derived suppressor cells. We identified protective and detrimental gene modules that defined distinct trajectories associated with mild versus severe outcomes. The interferon response was decoupled from the protective host response in patients with severe outcomes. These findings were consistent, irrespective of age and virus, and provide insights to accelerate the development of diagnostics and host-directed therapies to improve global pandemic preparedness. |Antigen Presentation/genetics[MESH] |Cohort Studies[MESH] |Hematopoiesis/genetics[MESH] |Humans[MESH] |Immunity/*genetics[MESH] |Interferons/blood[MESH] |Killer Cells, Natural/immunology/pathology[MESH] |Myeloid Cells/immunology/pathology[MESH] |Prognosis[MESH] |Severity of Illness Index[MESH] |Systems Biology[MESH] |Transcriptome[MESH] |Virus Diseases/blood/classification/genetics/*immunology[MESH]Multi-cohort analysis of host immune response identifies conserved pro(epmc).pdf DeepDyve Pubget Overpricing