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10.1371/journal.ppat.1009383 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009383 33765062!8023494!33765062     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2021 ; 17 (3): e1009383 Nephropedia Template TP {{tp|p=33765062|t=2021. Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model |pdf=|usr=}}{{33765062}} gab.com Text Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33765062 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although human disease is often asymptomatic, some develop severe illnesses such as pneumonia, respiratory failure, and death. There is an urgent need for a vaccine to prevent its rapid spread as asymptomatic infections accounting for up to 40% of transmission events. Here we further evaluated an inactivated rabies vectored SARS-CoV-2 S1 vaccine CORAVAX in a Syrian hamster model. CORAVAX adjuvanted with MPLA-AddaVax, a TRL4 agonist, induced high levels of neutralizing antibodies and generated a strong Th1-biased immune response. Vaccinated hamsters were protected from weight loss and viral replication in the lungs and nasal turbinates three days after challenge with SARS-CoV-2. CORAVAX also prevented lung disease, as indicated by the significant reduction in lung pathology. This study highlights CORAVAX as a safe, immunogenic, and efficacious vaccine that warrants further assessment in human trials. Twit Text FOAVip Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33765062 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33765062 #FOAvip English Wikipedia <ref>{{Cite pmid|33765062}}</ref> Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model #MMPMID33765062 Kurup D; Malherbe DC; Wirblich C; Lambert R; Ronk AJ; Zabihi Diba L; Bukreyev A; Schnell MJ PLoS Pathog 2021[Mar]; 17 (3): e1009383 PMID33765062show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although human disease is often asymptomatic, some develop severe illnesses such as pneumonia, respiratory failure, and death. There is an urgent need for a vaccine to prevent its rapid spread as asymptomatic infections accounting for up to 40% of transmission events. Here we further evaluated an inactivated rabies vectored SARS-CoV-2 S1 vaccine CORAVAX in a Syrian hamster model. CORAVAX adjuvanted with MPLA-AddaVax, a TRL4 agonist, induced high levels of neutralizing antibodies and generated a strong Th1-biased immune response. Vaccinated hamsters were protected from weight loss and viral replication in the lungs and nasal turbinates three days after challenge with SARS-CoV-2. CORAVAX also prevented lung disease, as indicated by the significant reduction in lung pathology. This study highlights CORAVAX as a safe, immunogenic, and efficacious vaccine that warrants further assessment in human trials. |*COVID-19/immunology/prevention & control[MESH] |Animals[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19 Vaccines/*immunology[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Mesocricetus[MESH] |Rabies virus/*immunology[MESH]Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease (epmc).pdf DeepDyve Pubget Overpricing