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10.1111/bcp.14831 http://scihub22266oqcxt.onion/10.1111/bcp.14831 33763917!8251044!33763917     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Clin+Pharmacol 2021 ; 87 (11): 4450-4454 Nephropedia Template TP {{tp|p=33763917|t=2021. Liver and kidney function in patients with Covid-19 treated with remdesivir |pdf=|usr=}}{{33763917}} gab.com Text Liver and kidney function in patients with Covid-19 treated with remdesivir JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33763917 #FOAvip For the treatment of Covid-19 patients with remdesivir, poor renal and liver function were both exclusion criteria in randomized clinical trials and contraindication for treatment. Also, nephrotoxicity and hepatotoxicity are reported as adverse events. We retrospectively reviewed renal and liver functions of Covid-19 103 patients who received remdesivir in the 15 days after treatment initiation. Approximately 20% of the patient population met randomized clinical trial exclusion criteria. In total, 11% of the patients had a decrease in estimated glomerular filtration rate >10 mL/min/1.73m(2) . Also, 25 and 35% had increased alanine transaminase and aspartate transaminase levels, respectively. However, serious adverse events were limited. Therefore, based on these preliminary results, contraindications based on kidney and liver function should not be absolute for remdesivir treatment in patients with Covid-19 if these functions are monitored regularly. A larger patient cohort is warranted to confirm our results. Twit Text FOAVip Liver and kidney function in patients with Covid-19 treated with remdesivir ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33763917 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33763917 #FOAvip English Wikipedia <ref>{{Cite pmid|33763917}}</ref> Liver and kidney function in patients with Covid-19 treated with remdesivir #MMPMID33763917 van Laar SA; de Boer MGJ; Gombert-Handoko KB; Guchelaar HJ; Zwaveling J Br J Clin Pharmacol 2021[Nov]; 87 (11): 4450-4454 PMID33763917show ga For the treatment of Covid-19 patients with remdesivir, poor renal and liver function were both exclusion criteria in randomized clinical trials and contraindication for treatment. Also, nephrotoxicity and hepatotoxicity are reported as adverse events. We retrospectively reviewed renal and liver functions of Covid-19 103 patients who received remdesivir in the 15 days after treatment initiation. Approximately 20% of the patient population met randomized clinical trial exclusion criteria. In total, 11% of the patients had a decrease in estimated glomerular filtration rate >10 mL/min/1.73m(2) . Also, 25 and 35% had increased alanine transaminase and aspartate transaminase levels, respectively. However, serious adverse events were limited. Therefore, based on these preliminary results, contraindications based on kidney and liver function should not be absolute for remdesivir treatment in patients with Covid-19 if these functions are monitored regularly. A larger patient cohort is warranted to confirm our results. |*COVID-19 Drug Treatment[MESH] |Adenosine Monophosphate/analogs & derivatives[MESH] |Alanine/analogs & derivatives[MESH] |Antiviral Agents/therapeutic use[MESH] |Humans[MESH] |Kidney[MESH] |Liver[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Liver and kidney function in patients with Covid-19 treated with remde(epmc).pdf DeepDyve Pubget Overpricing