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10.3389/fimmu.2021.648546

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.648546
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33763085!7982656!33763085
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suck abstract from ncbi


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pmid33763085      Front+Immunol 2021 ; 12 (ä): 648546
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  • Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C) #MMPMID33763085
  • Feketea G; Vlacha V; Bocsan IC; Vassilopoulou E; Stanciu LA; Zdrenghea M
  • Front Immunol 2021[]; 12 (ä): 648546 PMID33763085show ga
  • Multisystem Inflammatory Syndrome in children (MIS-C) is a rare but devastating complication of coronavirus disease 19 (COVID-19). The development of prognostic biomarkers and more importantly the implementation of new treatment modalities would have a significant impact in clinical practice regarding the outcome of MIS-C. Vitamin D could be a potential candidate. In this mini review we analyze the immunomodulatory role of vitamin D in viral infections and specifically in COVID-19. We also examine the current literature regarding the association of vitamin D with MIS-C and Kawasaki disease. The vitamin D was evaluated not only as a biomarker but also as a nutritional supplement. We concluded that vitamin D levels could be valuable in predicting severe forms of MIS-C and correction of abnormal levels in severe MIS-C may influences its evolution. 25-hydroxyvitamin D3 [25(OH)D3] supplementation raising serum [25(OH)D] concentrations potentially have a favorable effect in reducing the severity of MIS-C in certain circumstances. Further studies are needed to confirm these results.
  • |Animals[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/blood/*complications/etiology/virology[MESH]
  • |Child[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2/physiology[MESH]
  • |Systemic Inflammatory Response Syndrome/blood/*drug therapy/*etiology[MESH]


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