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10.3389/fimmu.2021.632814 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.632814 33763078!7982848!33763078     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 632814 Nephropedia Template TP {{tp|p=33763078|t=2021. The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 Patients |pdf=|usr=}}{{33763078}} gab.com Text The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 Patients JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33763078 #FOAvip Increasing evidence suggests that dysregulated immune responses are associated with the clinical outcome of coronavirus disease 2019 (COVID-19). Nucleocapsid protein (NP)-, spike (S)-, receptor binding domain (RBD)- specific immunoglobulin (Ig) isotypes, IgG subclasses and neutralizing antibody (NAb) were analyzed in 123 serum from 63 hospitalized patients with severe, moderate, mild or asymptomatic COVID-19. Mild to modest correlations were found between disease severity and antigen specific IgG subclasses in serum, of which IgG1 and IgG3 were negatively associated with viral load in nasopharyngeal swab. Multiple cytokines were significantly related with antigen-specific Ig isotypes and IgG subclasses, and IL-1beta was positively correlated with most antibodies. Furthermore, the old patients (>/= 60 years old) had higher levels of chemokines, increased NAb activities and SARS-CoV-2 specific IgG1, and IgG3 responses and compromised T cell responses compared to the young patients (</= 18 years old), which are related with more severe cases. Higher IgG1 and IgG3 were found in COVID-19 patients with comorbidities while biological sex had no effect on IgG subclasses. Overall, we have identified diseases severity was related to higher antibodies, of which IgG subclasses had weakly negative correlation with viral load, and cytokines were significantly associated with antibody response. Further, advancing age and comorbidities had obvious effect on IgG1 and IgG3. Twit Text FOAVip The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 Patients ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33763078 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33763078 #FOAvip English Wikipedia <ref>{{Cite pmid|33763078}}</ref> The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 Patients #MMPMID33763078 Luo H; Jia T; Chen J; Zeng S; Qiu Z; Wu S; Li X; Lei Y; Wang X; Wu W; Zhang R; Zou X; Feng T; Ding R; Zhang Y; Chen YQ; Sun C; Wang T; Fang S; Shu Y Front Immunol 2021[]; 12 (ä): 632814 PMID33763078show ga Increasing evidence suggests that dysregulated immune responses are associated with the clinical outcome of coronavirus disease 2019 (COVID-19). Nucleocapsid protein (NP)-, spike (S)-, receptor binding domain (RBD)- specific immunoglobulin (Ig) isotypes, IgG subclasses and neutralizing antibody (NAb) were analyzed in 123 serum from 63 hospitalized patients with severe, moderate, mild or asymptomatic COVID-19. Mild to modest correlations were found between disease severity and antigen specific IgG subclasses in serum, of which IgG1 and IgG3 were negatively associated with viral load in nasopharyngeal swab. Multiple cytokines were significantly related with antigen-specific Ig isotypes and IgG subclasses, and IL-1beta was positively correlated with most antibodies. Furthermore, the old patients (>/= 60 years old) had higher levels of chemokines, increased NAb activities and SARS-CoV-2 specific IgG1, and IgG3 responses and compromised T cell responses compared to the young patients ( |Adolescent[MESH] |Adult[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/*immunology/pathology/virology[MESH] |Child[MESH] |China[MESH] |Cytokines/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/immunology[MESH] |Immunoglobulin G/*immunology[MESH] |Immunoglobulin M/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/immunology/*physiology[MESH] |Severity of Illness Index[MESH] |T-Lymphocytes/immunology[MESH]The Characterization of Disease Severity Associated IgG Subclasses Res(epmc).pdf DeepDyve Pubget Overpricing