Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Microbiol 2021 ; 12 (ä): 657439 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Epidemiological Study of Betacoronaviruses in Captive Malayan Pangolins #MMPMID33763052
Li L; Wang X; Hua Y; Liu P; Zhou J; Chen J; An F; Hou F; Huang W; Chen J
Front Microbiol 2021[]; 12 (ä): 657439 PMID33763052show ga
The coronavirus disease 2019 (COVID-19) outbreak has significantly affected international public health safety. It has been reported that the pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, could originate from bats and utilize the Malayan pangolin (Manis javanica) as an intermediate host. To gain further insights into the coronaviruses carried by pangolins, we investigated the occurrence of Betacoronavirus (beta-CoV) infections in captive Malayan pangolins in the Guangdong province of China. We detected three beta-CoV-positive M. javanica individuals with a positive rate of 6.98% and also detected beta-CoV in two dead pangolins sampled in August 2019. The CoV carried by pangolins is a new beta-CoV, which is genetically related to SARS-CoV-2. Furthermore, the expression of angiotensin-converting enzyme 2 (ACE2) was detected in eight organs of pangolins, with the highest ACE2 mRNA levels in the kidney, suggesting that these organs could be at a risk of beta-CoV infection. These results enable us to better understand the status of beta-CoV carried by Malayan pangolins, while providing a theoretical basis for better pangolin protection and viral control.