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10.2147/DDDT.S293216

http://scihub22266oqcxt.onion/10.2147/DDDT.S293216
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33762818!7982566!33762818
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suck abstract from ncbi


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pmid33762818      Drug+Des+Devel+Ther 2021 ; 15 (ä): 1213-1223
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  • Potential Anti-Coronavirus Agents and the Pharmacologic Mechanisms #MMPMID33762818
  • Yang Y; Cui X; Wei H; Guo C; Zhang Y
  • Drug Des Devel Ther 2021[]; 15 (ä): 1213-1223 PMID33762818show ga
  • Severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) is an emerging pathogen, which is similar to previous SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) occurrences. However, we only get few understandings about the pathogenesis of SARS-CoV-2, which need to further be studied. The discovery of an agent that has a treatment efficacy against SARS-CoV-2 is very urgent. In this review, we briefly discuss the virology of this pathogen and focus on the available understanding of the pathogenesis and treatments of this pathogen including the uses of nucleoside analogues, protease inhibitors, interferons, and other small-molecule drugs, on the basis previous comprehensions of SARS and MERS. These reviewed concepts may be beneficial in providing new insights and potential treatments for COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |Angiotensin-Converting Enzyme 2/physiology[MESH]
  • |Antiviral Agents/*pharmacology/therapeutic use[MESH]
  • |COVID-19/pathology[MESH]
  • |Coronavirus RNA-Dependent RNA Polymerase/antagonists & inhibitors[MESH]
  • |Humans[MESH]


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