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10.1097/MD.0000000000025173

http://scihub22266oqcxt.onion/10.1097/MD.0000000000025173
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33761696!9282040!33761696
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suck abstract from ncbi


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pmid33761696      Medicine+(Baltimore) 2021 ; 100 (12): e25173
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  • Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: Case report #MMPMID33761696
  • Sari AP; Darnindro N; Yohanes A; Mokoagow MI
  • Medicine (Baltimore) 2021[Mar]; 100 (12): e25173 PMID33761696show ga
  • RATIONALE: Bacterial and fungal infections in Coronavirus Disease-19 (COVID-19) patients have been inadequately investigated and reported thus far. The safety profile of tocilizumab (TCZ) administration in candidemia patient still debatable. PATIENT CONCERNS: A 54 year-old woman presenting with weakness on the left side of her body was diagnosed with COVID-19. After 7 days of admission, her condition worsened and developed respiratory distress and was having respiratory distress despite standard treatment. DIAGNOSES: Acute respiratory distress syndrome (ARDS) in COVID 19 was diagnoses based on real time-PCR swab, deterioration of PaO2/FiO2 and increased of acute phase reactants. INTERVENTIONS: Anti Interleukin-6 (IL-6) was considered to tackle her inflammatory condition. Prior to TCZ administration, blood culture was performed and the result came with Candida tropicalis in the absence of bacterial growth. OUTCOMES: No major complications associated with intravenous antifungal or TCZ occurred. After 40 days of hospitalization, the patient's clinical condition improved and was finally discharged. LESSONS: This case underscores the safety profile of giving TCZ in candidemia as a secondary infection in severe COVID-19 patient.
  • |*COVID-19 Drug Treatment[MESH]
  • |Antibodies, Monoclonal, Humanized/adverse effects/*therapeutic use[MESH]
  • |Antifungal Agents/*therapeutic use[MESH]
  • |COVID-19/*complications[MESH]
  • |Candida tropicalis[MESH]
  • |Candidemia/*complications/*drug therapy[MESH]
  • |Coinfection[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interleukin-6/*antagonists & inhibitors[MESH]
  • |Micafungin/therapeutic use[MESH]
  • |Middle Aged[MESH]


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