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10.1097/MD.0000000000025170 http://scihub22266oqcxt.onion/10.1097/MD.0000000000025170 33761694!9281988!33761694     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Medicine+(Baltimore) 2021 ; 100 (12): e25170 Nephropedia Template TP {{tp|p=33761694|t=2021. Hemophagocytic lymphohistiocytosis in COVID-19: Case reports of a stepwise approach |pdf=|usr=}}{{33761694}} gab.com Text Hemophagocytic lymphohistiocytosis in COVID-19: Case reports of a stepwise approach JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=33761694 #FOAvip RATIONALE: The immunologic syndrome induced by severe acute coronavirus disease 2019 (COVID-19) is yet not fully understood. Typical patterns of clinical and laboratory features match secondary hemophagocytic lymphohistiocytosis (sHLH). However, the optimal approach to COVID-19 patients testing positive for sHLH is still unclear. PATIENT CONCERNS: Three patients with COVID-19 are reviewed. All showed hyperinflammation and cytokine storm, necessitating intensive care treatment including mechanical ventilation. DIAGNOSIS: Secondary hemophagocytic lymphohistiocytosis due to severe COVID-19; diagnosed via HScore. INTERVENTIONS: A treatment regimen of methylprednisolone, pentaglobin, and anakinra was developed and administered. OUTCOMES: One patient survived the ICU stay. Two other patients, in whom sHLH was diagnosed too late, deceased. LESSONS: A routine screening of COVID-19 patients for secondary HLH by using the HScore is feasible; especially those patients deteriorating clinically with no sufficient response to shock management might be at particular high risk. A stepwise therapeutic approach comprising corticosteroids, immunoglobulins and anakinra, accompanied by immunoadsorption, may dampen cytokine storm effects, and potentially reduce mortality. Twit Text FOAVip Hemophagocytic lymphohistiocytosis in COVID-19: Case reports of a stepwise approach ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=33761694 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33761694 #FOAvip English Wikipedia <ref>{{Cite pmid|33761694}}</ref> Hemophagocytic lymphohistiocytosis in COVID-19: Case reports of a stepwise approach #MMPMID33761694 Schnaubelt S; Tihanyi D; Strassl R; Schmidt R; Anders S; Laggner AN; Agis H; Domanovits H Medicine (Baltimore) 2021[Mar]; 100 (12): e25170 PMID33761694show ga RATIONALE: The immunologic syndrome induced by severe acute coronavirus disease 2019 (COVID-19) is yet not fully understood. Typical patterns of clinical and laboratory features match secondary hemophagocytic lymphohistiocytosis (sHLH). However, the optimal approach to COVID-19 patients testing positive for sHLH is still unclear. PATIENT CONCERNS: Three patients with COVID-19 are reviewed. All showed hyperinflammation and cytokine storm, necessitating intensive care treatment including mechanical ventilation. DIAGNOSIS: Secondary hemophagocytic lymphohistiocytosis due to severe COVID-19; diagnosed via HScore. INTERVENTIONS: A treatment regimen of methylprednisolone, pentaglobin, and anakinra was developed and administered. OUTCOMES: One patient survived the ICU stay. Two other patients, in whom sHLH was diagnosed too late, deceased. LESSONS: A routine screening of COVID-19 patients for secondary HLH by using the HScore is feasible; especially those patients deteriorating clinically with no sufficient response to shock management might be at particular high risk. A stepwise therapeutic approach comprising corticosteroids, immunoglobulins and anakinra, accompanied by immunoadsorption, may dampen cytokine storm effects, and potentially reduce mortality. |Aged[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |COVID-19/*complications/physiopathology/therapy[MESH] |Combined Modality Therapy[MESH] |Critical Care[MESH] |Cytokine Release Syndrome/drug therapy[MESH] |Delayed Diagnosis[MESH] |Fatal Outcome[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/therapeutic use[MESH] |Immunoglobulin M/therapeutic use[MESH] |Immunoglobulins, Intravenous/therapeutic use[MESH] |Immunosuppressive Agents/therapeutic use[MESH] |Interleukin 1 Receptor Antagonist Protein/therapeutic use[MESH] |Lymphohistiocytosis, Hemophagocytic/diagnosis/*drug therapy/*etiology[MESH] |Male[MESH] |Methylprednisolone/therapeutic use[MESH] |Middle Aged[MESH] |Respiration, Artificial[MESH]Hemophagocytic lymphohistiocytosis in COVID-19: Case reports of a step(epmc).pdf DeepDyve Pubget Overpricing