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10.1016/j.biopha.2021.111384 http://scihub22266oqcxt.onion/10.1016/j.biopha.2021.111384 33761605!7881701!33761605     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33761605&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Pharmacother 2021 ; 137 (ä): 111384 Nephropedia Template TP {{tp|p=33761605|t=2021. Heme oxygenase-1 inducer hemin does not inhibit SARS-CoV-2 virus infection |pdf=|usr=}}{{33761605}} gab.com Text Heme oxygenase-1 inducer hemin does not inhibit SARS-CoV-2 virus infection JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=33761605 #FOAvip Antiviral agents with different mechanisms of action could induce synergistic effects against SARS-CoV-2 infection. Some reports suggest the therapeutic potential of the heme oxygenase-1 (HO-1) enzyme against virus infection. Given that hemin is a natural inducer of the HO-1 gene, the aim of this study was to develop an in vitro assay to analyze the antiviral potency of hemin against SARS-CoV-2 infection. A SARS-CoV-2 infectivity assay was conducted in Vero-E6 and Calu-3 epithelial cell lines. The antiviral effect of hemin, and chloroquine as a control, against SARS-CoV-2 virus infection was quantified by RT-qPCR using specific oligonucleotides for the N gene. Chloroquine induced a marked reduction of viral genome copies in kidney epithelial Vero-E6 cells but not in lung cancer Calu-3 cells. Hemin administration to the culture medium induced a high induction in the expression of the HO-1 gene that was stronger in Vero-E6 macaque-derived cells than in the human Calu-3 cell line. However, hemin treatment did not modify SARS-CoV-2 replication, as measured by viral genome quantification 48 h post-infection for Vero-E6 and 72 h post-infection for the Calu-3 lineages. In conclusion, although exposure to hemin induced strong HO-1 up-regulation, this effect was unable to inhibit or delay the progression of SARS-CoV-2 infection in two epithelial cell lines susceptible to infection. Twit Text FOAVip Heme oxygenase-1 inducer hemin does not inhibit SARS-CoV-2 virus infection ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=33761605 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33761605 #FOAvip English Wikipedia <ref>{{Cite pmid|33761605}}</ref> Heme oxygenase-1 inducer hemin does not inhibit SARS-CoV-2 virus infection #MMPMID33761605 Maestro S; Cordoba KM; Olague C; Argemi J; Avila MA; Gonzalez-Aseguinolaza G; Smerdou C; Fontanellas A Biomed Pharmacother 2021[May]; 137 (ä): 111384 PMID33761605show ga Antiviral agents with different mechanisms of action could induce synergistic effects against SARS-CoV-2 infection. Some reports suggest the therapeutic potential of the heme oxygenase-1 (HO-1) enzyme against virus infection. Given that hemin is a natural inducer of the HO-1 gene, the aim of this study was to develop an in vitro assay to analyze the antiviral potency of hemin against SARS-CoV-2 infection. A SARS-CoV-2 infectivity assay was conducted in Vero-E6 and Calu-3 epithelial cell lines. The antiviral effect of hemin, and chloroquine as a control, against SARS-CoV-2 virus infection was quantified by RT-qPCR using specific oligonucleotides for the N gene. Chloroquine induced a marked reduction of viral genome copies in kidney epithelial Vero-E6 cells but not in lung cancer Calu-3 cells. Hemin administration to the culture medium induced a high induction in the expression of the HO-1 gene that was stronger in Vero-E6 macaque-derived cells than in the human Calu-3 cell line. However, hemin treatment did not modify SARS-CoV-2 replication, as measured by viral genome quantification 48 h post-infection for Vero-E6 and 72 h post-infection for the Calu-3 lineages. In conclusion, although exposure to hemin induced strong HO-1 up-regulation, this effect was unable to inhibit or delay the progression of SARS-CoV-2 infection in two epithelial cell lines susceptible to infection. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19[MESH] |Cell Line[MESH] |Cells, Cultured[MESH] |Chlorocebus aethiops[MESH] |Chloroquine/pharmacology[MESH] |Epithelial Cells/drug effects/metabolism[MESH] |Heme Oxygenase-1/*metabolism[MESH] |Hemin/*pharmacology[MESH] |Humans[MESH] |Lung/drug effects[MESH] |SARS-CoV-2/*drug effects[MESH] |Vero Cells[MESH]Heme oxygenase-1 inducer hemin does not inhibit SARS-CoV-2 virus infec(epmc).pdf DeepDyve Pubget Overpricing