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10.1007/s00705-021-05029-7

http://scihub22266oqcxt.onion/10.1007/s00705-021-05029-7
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33761008!7988246!33761008
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suck abstract from ncbi


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pmid33761008      Arch+Virol 2021 ; 166 (6): 1735-1739
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  • Diverse SARS-CoV-2 variants preceded the initial COVID-19 outbreak in Croatia #MMPMID33761008
  • Rokic F; Trgovec-Greif L; Sucic N; Cemeljic N; Grbesa DC; Svedruzic Z; Rukavina T; Vugrek O; Jurak I
  • Arch Virol 2021[Jun]; 166 (6): 1735-1739 PMID33761008show ga
  • We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with different SARS-CoV-2 variants belonging to different clades (mostly G and GH). This result confirms that there was widespread virus transmission early in 2020. Interestingly, we identified a unique mutation resulting in a V13I substitution in Nsp5A, the main viral protease, in a patient who had not received antiviral therapy.
  • |*Genetic Variation[MESH]
  • |COVID-19/*epidemiology/*virology[MESH]
  • |Coronavirus 3C Proteases/chemistry[MESH]
  • |Croatia/epidemiology[MESH]
  • |Genome, Viral[MESH]
  • |Humans[MESH]
  • |Models, Molecular[MESH]
  • |Phylogeny[MESH]
  • |Protein Conformation[MESH]
  • |SARS-CoV-2/*genetics[MESH]


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