Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.ppat.1009392 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009392 33760889!7990223!33760889     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2021 ; 17 (3): e1009392 Nephropedia Template TP {{tp|p=33760889|t=2021. Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry |pdf=|usr=}}{{33760889}} gab.com Text Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33760889 #FOAvip Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species-specific manner. We and others have previously shown that ACE2 orthologs from New World monkey, koala and mouse cannot interact with SARS-CoV-2 to mediate viral entry, and this defect can be restored by humanization of the restrictive residues in New World monkey ACE2. To better understand the genetic determinants behind the ability of ACE2 orthologs to support viral entry, we compared koala and mouse ACE2 sequences with that of human and identified the key residues in koala and mouse ACE2 that restrict viral receptor activity. Humanization of these critical residues rendered both koala and mouse ACE2 capable of binding the spike protein and facilitating viral entry. Our study shed more lights into the genetic determinants of ACE2 as the functional receptor of SARS-CoV-2, which facilitates our understanding of viral entry. Twit Text FOAVip Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33760889 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33760889 #FOAvip English Wikipedia <ref>{{Cite pmid|33760889}}</ref> Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry #MMPMID33760889 Ren W; Zhu Y; Wang Y; Shi H; Yu Y; Hu G; Feng F; Zhao X; Lan J; Wu J; Kenney DJ; Douam F; Tong Y; Zhong J; Xie Y; Wang X; Yuan Z; Zhou D; Zhang R; Ding Q PLoS Pathog 2021[Mar]; 17 (3): e1009392 PMID33760889show ga Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species-specific manner. We and others have previously shown that ACE2 orthologs from New World monkey, koala and mouse cannot interact with SARS-CoV-2 to mediate viral entry, and this defect can be restored by humanization of the restrictive residues in New World monkey ACE2. To better understand the genetic determinants behind the ability of ACE2 orthologs to support viral entry, we compared koala and mouse ACE2 sequences with that of human and identified the key residues in koala and mouse ACE2 that restrict viral receptor activity. Humanization of these critical residues rendered both koala and mouse ACE2 capable of binding the spike protein and facilitating viral entry. Our study shed more lights into the genetic determinants of ACE2 as the functional receptor of SARS-CoV-2, which facilitates our understanding of viral entry. |Animals[MESH] |Base Sequence[MESH] |COVID-19/*enzymology/*genetics/virology[MESH] |Host Specificity[MESH] |Humans[MESH] |Mice/genetics/virology[MESH] |Peptidyl-Dipeptidase A/chemistry/*genetics/metabolism[MESH] |Phascolarctidae/genetics/virology[MESH] |Receptors, Virus/*genetics/metabolism[MESH] |SARS-CoV-2/genetics/*physiology[MESH] |Sequence Alignment[MESH] |Spike Glycoprotein, Coronavirus/genetics/metabolism[MESH]Comparative analysis reveals the species-specific genetic determinants(epmc).pdf DeepDyve Pubget Overpricing