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10.1080/14787210.2021.1908127

http://scihub22266oqcxt.onion/10.1080/14787210.2021.1908127
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suck abstract from ncbi


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pmid33759682      Expert+Rev+Anti+Infect+Ther 2021 ; 19 (10): 1325-1330
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  • Low pH Hypromellose (Taffix) nasal powder spray could reduce SARS-CoV-2 infection rate post mass-gathering event at a highly endemic community: an observational prospective open label user survey #MMPMID33759682
  • Shmuel K; Dalia M; Tair L; Yaakov N
  • Expert Rev Anti Infect Ther 2021[Oct]; 19 (10): 1325-1330 PMID33759682show ga
  • Objectives: Bney Brak city tops Israel's COVID-19 infection rate and mortality. Before the Jewish New Year (two-day gathering) SARS-CoV-2 PCR positivity rates were 17.6% and reached 28.1% two weeks later Taffix - an innovative nasal powder creates a protective gel over the nasal mucosa blocking viruses from infecting nasal cells, was tested for efficacy in preventing SARS CoV2 infection.Methods: In a prospective users survey, 243 members of an ultra-orthodox community that participated in two days prayers were followed for 14 days following this 'superspread' event. Eighty-three used Taffix throughout holiday's prayers and the following two weeks (ITT). Eighty-one used it regularly (PP). Two used it rarely if at all. The remaining 160 did not use Taffix.Results: After 14 days, 0/81 (0%) of (PP) Tafffix users, 2/83 (2.4%) of (ITT) Taffix users and 16/160 (10%) nonusers were infected. Odds ratio for infection among Taffix users was 0.22, a reduction of 78% (95%CI 1%-95%). No side effects reported.Conclusion: Taffix could be an additional tool against COVID19 spread, in addition to recommended safety measures. This is the first time that a prevention measure of SARS-CoV-2, beyond the use of masks, has proved effective.
  • |Administration, Intranasal[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |COVID-19/epidemiology/*prevention & control[MESH]
  • |Endemic Diseases/*prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hypromellose Derivatives/administration & dosage/*therapeutic use[MESH]
  • |Israel/epidemiology[MESH]
  • |Male[MESH]
  • |Medication Adherence[MESH]
  • |Middle Aged[MESH]
  • |Nasal Sprays[MESH]
  • |Powders[MESH]
  • |Prospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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