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10.1111/jcmm.16444

http://scihub22266oqcxt.onion/10.1111/jcmm.16444
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33759345!8107096!33759345
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suck abstract from ncbi


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pmid33759345      J+Cell+Mol+Med 2021 ; 25 (10): 4753-4764
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  • Risk stratification by long non-coding RNAs profiling in COVID-19 patients #MMPMID33759345
  • Cheng J; Zhou X; Feng W; Jia M; Zhang X; An T; Luan M; Pan Y; Zhang S; Zhou Z; Wen L; Sun Y; Zhou C
  • J Cell Mol Med 2021[May]; 25 (10): 4753-4764 PMID33759345show ga
  • Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic worldwide. Long non-coding RNAs (lncRNAs) are a subclass of endogenous, non-protein-coding RNA, which lacks an open reading frame and is more than 200 nucleotides in length. However, the functions for lncRNAs in COVID-19 have not been unravelled. The present study aimed at identifying the related lncRNAs based on RNA sequencing of peripheral blood mononuclear cells from patients with SARS-CoV-2 infection as well as health individuals. Overall, 17 severe, 12 non-severe patients and 10 healthy controls were enrolled in this study. Firstly, we reported some altered lncRNAs between severe, non-severe COVID-19 patients and healthy controls. Next, we developed a 7-lncRNA panel with a good differential ability between severe and non-severe COVID-19 patients using least absolute shrinkage and selection operator regression. Finally, we observed that COVID-19 is a heterogeneous disease among which severe COVID-19 patients have two subtypes with similar risk score and immune score based on lncRNA panel using iCluster algorithm. As the roles of lncRNAs in COVID-19 have not yet been fully identified and understood, our analysis should provide valuable resource and information for the future studies.
  • |*RNA, Long Noncoding/blood/physiology[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/*diagnosis[MESH]
  • |Case-Control Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Risk Assessment[MESH]


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