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10.1016/j.nantod.2021.101139 http://scihub22266oqcxt.onion/10.1016/j.nantod.2021.101139 33758593!7972805!33758593     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nano+Today 2021 ; 38 (ä): 101139 Nephropedia Template TP {{tp|p=33758593|t=2021. Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus |pdf=|usr=}}{{33758593}} gab.com Text Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus JO: Nano Today http://www.kidney.de/pget.php?&tw=1&pmid=33758593 #FOAvip Effective vaccines are vital to fight against the COVID-19 global pandemic. As a critical component of a subunit vaccine, the adjuvant is responsible for strengthening the antigen-induced immune responses. Here, we present a new nanovaccine that comprising the Receptor-Binding Domain (RBD) of spike protein and the manganese nanoadjuvant (MnARK), which induces humoral and cellular responses. Notably, even at a 5-fold lower antigen dose and with fewer injections, the MnARK vaccine immunized mice showed stronger neutralizing abilities against the infection of the pseudovirus (~270-fold) and live coronavirus (>8-fold) in vitro than that of Alum-adsorbed RBD vaccine (Alu-RBD). Furthermore, we found that the effective co-delivery of RBD antigen and MnARK to lymph nodes (LNs) elicited an increased cellular internalization and the activation of immune cells, including DCs, CD4(+) and CD8(+) T lymphocytes. Our findings highlight the importance of MnARK adjuvant in the design of novel coronavirus vaccines and provide a rationale strategy to design protective vaccines through promoting cellular internalization and the activation of immune-related pathways. Twit Text FOAVip Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus ????Nano Today http://www.kidney.de/pget.php?&tw=1&pmid=33758593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33758593 #FOAvip English Wikipedia <ref>{{Cite pmid|33758593}}</ref> Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus #MMPMID33758593 Wang Y; Xie Y; Luo J; Guo M; Hu X; Chen X; Chen Z; Lu X; Mao L; Zhang K; Wei L; Ma Y; Wang R; Zhou J; He C; Zhang Y; Zhang Y; Chen S; Shen L; Chen Y; Qiu N; Liu Y; Cui Y; Liao G; Liu Y; Chen C Nano Today 2021[Jun]; 38 (ä): 101139 PMID33758593show ga Effective vaccines are vital to fight against the COVID-19 global pandemic. As a critical component of a subunit vaccine, the adjuvant is responsible for strengthening the antigen-induced immune responses. Here, we present a new nanovaccine that comprising the Receptor-Binding Domain (RBD) of spike protein and the manganese nanoadjuvant (MnARK), which induces humoral and cellular responses. Notably, even at a 5-fold lower antigen dose and with fewer injections, the MnARK vaccine immunized mice showed stronger neutralizing abilities against the infection of the pseudovirus (~270-fold) and live coronavirus (>8-fold) in vitro than that of Alum-adsorbed RBD vaccine (Alu-RBD). Furthermore, we found that the effective co-delivery of RBD antigen and MnARK to lymph nodes (LNs) elicited an increased cellular internalization and the activation of immune cells, including DCs, CD4(+) and CD8(+) T lymphocytes. Our findings highlight the importance of MnARK adjuvant in the design of novel coronavirus vaccines and provide a rationale strategy to design protective vaccines through promoting cellular internalization and the activation of immune-related pathways. äEngineering a self-navigated MnARK nanovaccine for inducing potent pro(epmc).pdf DeepDyve Pubget Overpricing