Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/scisignal.abd5605 http://scihub22266oqcxt.onion/10.1126/scisignal.abd5605 33758061!8315109!33758061     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2021 ; 14 (675): ä Nephropedia Template TP {{tp|p=33758061|t=2021. Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling |pdf=|usr=}}{{33758061}} gab.com Text Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=33758061 #FOAvip Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca(2+) from acidic organelles through the activation of two-pore channels (TPCs) to regulate endolysosomal trafficking events. NAADP action is mediated by NAADP-binding protein(s) of unknown identity that confer NAADP sensitivity to TPCs. Here, we used a "clickable" NAADP-based photoprobe to isolate human NAADP-binding proteins and identified Jupiter microtubule-associated homolog 2 (JPT2) as a TPC accessory protein required for endogenous NAADP-evoked Ca(2+) signaling. JPT2 was also required for the translocation of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudovirus through the endolysosomal system. Thus, JPT2 is a component of the NAADP receptor complex that is essential for TPC-dependent Ca(2+) signaling and control of coronaviral entry. Twit Text FOAVip Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=33758061 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33758061 #FOAvip English Wikipedia <ref>{{Cite pmid|33758061}}</ref> Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling #MMPMID33758061 Gunaratne GS; Brailoiu E; He S; Unterwald EM; Patel S; Slama JT; Walseth TF; Marchant JS Sci Signal 2021[Mar]; 14 (675): ä PMID33758061show ga Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca(2+) from acidic organelles through the activation of two-pore channels (TPCs) to regulate endolysosomal trafficking events. NAADP action is mediated by NAADP-binding protein(s) of unknown identity that confer NAADP sensitivity to TPCs. Here, we used a "clickable" NAADP-based photoprobe to isolate human NAADP-binding proteins and identified Jupiter microtubule-associated homolog 2 (JPT2) as a TPC accessory protein required for endogenous NAADP-evoked Ca(2+) signaling. JPT2 was also required for the translocation of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudovirus through the endolysosomal system. Thus, JPT2 is a component of the NAADP receptor complex that is essential for TPC-dependent Ca(2+) signaling and control of coronaviral entry. |Affinity Labels[MESH] |Animals[MESH] |COVID-19/*metabolism/*virology[MESH] |Calcium Channels/metabolism[MESH] |Calcium Signaling/*physiology[MESH] |Carrier Proteins/metabolism[MESH] |Click Chemistry/methods[MESH] |Gene Knockdown Techniques[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Microtubule-Associated Proteins/antagonists & inhibitors/genetics/*metabolism[MESH] |NADP/*analogs & derivatives/metabolism[MESH] |Recombinant Proteins/genetics/metabolism[MESH] |SARS-CoV-2/*physiology[MESH] |Second Messenger Systems/physiology[MESH] |Transcriptome[MESH]Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling (epmc).pdf DeepDyve Pubget Overpricing