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10.1016/j.jamda.2021.02.019

http://scihub22266oqcxt.onion/10.1016/j.jamda.2021.02.019
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suck abstract from ncbi


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pmid33757725      J+Am+Med+Dir+Assoc 2021 ; 22 (5): 943-947.e3
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  • Increase in Frailty in Nursing Home Survivors of Coronavirus Disease 2019: Comparison With Noninfected Residents #MMPMID33757725
  • Greco GI; Noale M; Trevisan C; Zatti G; Dalla Pozza M; Lazzarin M; Haxhiaj L; Ramon R; Imoscopi A; Bellon S; Maggi S; Sergi G
  • J Am Med Dir Assoc 2021[May]; 22 (5): 943-947.e3 PMID33757725show ga
  • OBJECTIVES: Institutionalized older adults have a high prevalence of frailty and disability, which may make them more vulnerable to the negative consequences of coronavirus disease 2019 (COVID-19). We investigated the impact of COVID-19 on the level of frailty, physical, and cognitive performance in nursing home residents. DESIGN: Nested case-control study. SETTING AND PARTICIPANTS: The study included nursing home residents who were infected with COVID-19 (case group, n = 76), matched by age to a control group (n = 76). METHODS: Participants' sociodemographic and medical data were collected, and they were also assessed for physical function (handgrip and walking speed), cognitive performance (Mini-Mental State Examination) and frailty (Frail-NH scale) before the first wave of the COVID-19 pandemic (October to December 2019, pre-COVID-19) and after (June to July 2020, post-COVID-19). COVID-19 symptoms and clinical course were recorded for the cases. RESULTS: Between the pre- and post-COVID-19 assessments, we found a 19% greater deterioration in handgrip, a 22% greater decrease in walking speed, and a 21% greater increase in Frail-NH scores in cases compared with controls. In both cases and controls, on the other hand, there was a significant 10% decrease in Mini-Mental State Examination scores over the study period. Multivariable logistic regression showed that COVID-19 survivors had a 4-fold increased chance of developing frailty compared with controls (odds ratio 4.95, 95% confidence interval 1.13-21.6, P = .03), but not cognitive decline. CONCLUSIONS AND IMPLICATIONS: COVID-19 can accelerate the aging process of institutionalized older adults in terms of physical performance and frailty by around 20%. However, we found similar levels of decline in cognitive performance in both cases and controls, likely because of the burden of social isolation and containment measures on neuropsychological health.
  • |*COVID-19[MESH]
  • |*Frailty/diagnosis/epidemiology[MESH]
  • |Aged[MESH]
  • |Case-Control Studies[MESH]
  • |Frail Elderly[MESH]
  • |Geriatric Assessment[MESH]
  • |Hand Strength[MESH]
  • |Humans[MESH]
  • |Nursing Homes[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]


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