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10.1016/j.tim.2021.03.001 http://scihub22266oqcxt.onion/10.1016/j.tim.2021.03.001 33757684!7980109!33757684     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33757684&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Trends+Microbiol 2021 ; 29 (11): 973-982 Nephropedia Template TP {{tp|p=33757684|t=2021. Interferon system deficiencies exacerbating severe pandemic virus infections |pdf=|usr=}}{{33757684}} gab.com Text Interferon system deficiencies exacerbating severe pandemic virus infections JO: Trends Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33757684 #FOAvip Pandemics are caused by novel pathogens to which pre-existing antibody immunity is lacking. Under these circumstances, the body must rely on innate interferon-mediated defenses to limit pathogen replication and allow development of critical humoral protection. Here, we highlight studies on disease susceptibility during H1N1 influenza and COVID-19 (SARS-CoV-2) pandemics. An emerging concept is that genetic and non-genetic deficiencies in interferon system components lead to uncontrolled virus replication and severe illness in a subset of people. Intriguingly, new findings suggest that individuals with autoantibodies neutralizing the antiviral function of interferon are at increased risk of severe COVID-19. We discuss key questions surrounding how such autoantibodies develop and function, as well as the general implications of diagnosing interferon deficiencies for personalized therapies. Twit Text FOAVip Interferon system deficiencies exacerbating severe pandemic virus infections ????Trends Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33757684 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33757684 #FOAvip English Wikipedia <ref>{{Cite pmid|33757684}}</ref> Interferon system deficiencies exacerbating severe pandemic virus infections #MMPMID33757684 Stertz S; Hale BG Trends Microbiol 2021[Nov]; 29 (11): 973-982 PMID33757684show ga Pandemics are caused by novel pathogens to which pre-existing antibody immunity is lacking. Under these circumstances, the body must rely on innate interferon-mediated defenses to limit pathogen replication and allow development of critical humoral protection. Here, we highlight studies on disease susceptibility during H1N1 influenza and COVID-19 (SARS-CoV-2) pandemics. An emerging concept is that genetic and non-genetic deficiencies in interferon system components lead to uncontrolled virus replication and severe illness in a subset of people. Intriguingly, new findings suggest that individuals with autoantibodies neutralizing the antiviral function of interferon are at increased risk of severe COVID-19. We discuss key questions surrounding how such autoantibodies develop and function, as well as the general implications of diagnosing interferon deficiencies for personalized therapies. |*Disease Resistance/immunology[MESH] |*Host-Pathogen Interactions/immunology[MESH] |Alleles[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Autoantibodies/immunology[MESH] |Autoimmunity[MESH] |Disease Progression[MESH] |Disease Susceptibility[MESH] |Genetic Predisposition to Disease[MESH] |Humans[MESH] |Interferons/antagonists & inhibitors/immunology/*metabolism[MESH] |Loss of Function Mutation[MESH] |Polymorphism, Single Nucleotide[MESH] |Severity of Illness Index[MESH]Interferon system deficiencies exacerbating severe pandemic virus infe(epmc).pdf DeepDyve Pubget Overpricing