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10.1177/1535370221999989

http://scihub22266oqcxt.onion/10.1177/1535370221999989
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33757336!8283249!33757336
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suck abstract from ncbi


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pmid33757336      Exp+Biol+Med+(Maywood) 2021 ; 246 (13): 1533-1540
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  • COVID-19: Antiviral agents and enzyme inhibitors/receptor blockers in development #MMPMID33757336
  • Jogalekar MP; Veerabathini A; Patel AB
  • Exp Biol Med (Maywood) 2021[Jul]; 246 (13): 1533-1540 PMID33757336show ga
  • Novel 2019 coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) and coronavirus disease 2019 (COVID-19), the respiratory syndrome it causes, have shaken the world to its core by infecting and claiming the lives of many people since originating in December 2019 in Wuhan, China. World Health Organization and several states have declared a pandemic situation and state of emergency, respectively. As there is no treatment for COVID-19, several research institutes and pharmaceutical companies are racing to find a cure. Advances in computational approaches have allowed the screening of massive antiviral compound libraries to identify those that may potentially work against SARS-CoV-2. Antiviral agents developed in the past to combat other viruses are being repurposed. At the same time, new vaccine candidates are being developed and tested in preclinical/clinical settings. This review provides a detailed overview of select repurposed drugs, their mechanism of action, associated toxicities, and major clinical trials involving these agents.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Drug Development[MESH]
  • |Angiotensin Receptor Antagonists/therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Enzyme Inhibitors/*therapeutic use[MESH]


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