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10.1097/TP.0000000000003770

http://scihub22266oqcxt.onion/10.1097/TP.0000000000003770
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33756548!8862677!33756548
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suck abstract from ncbi


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pmid33756548      Transplantation 2022 ; 106 (3): 641-647
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  • Characteristics and Outcomes of Heart Transplant Recipients With Coronavirus-19 Disease in a High-volume Transplant Center #MMPMID33756548
  • Marcondes-Braga FG; Murad CM; Belfort DSP; Dantas RCT; Lira MTSS; Aragao CAS; Siciliano RF; Mangini S; Seguro LFBC; Campos IW; Avila MS; Bello MVO; Dos Santos FBA; Strabelli TMV; Gaiotto FA; Bacal F
  • Transplantation 2022[Mar]; 106 (3): 641-647 PMID33756548show ga
  • BACKGROUND: Heart transplant (HT) recipients may be at higher risk of acquiring SARS-CoV-2 infection and developing critical illness. The aim of this study is to describe characteristics and outcomes of HT recipients infected by SARS-COV-2, from a high-volume transplant center. METHODS: We have described data of all adult HT recipients with confirmed coronavirus disease 2019 by RT-PCR in nasopharyngeal samples from April 5, 2020, to January 5, 2021. Outcomes and follow-up were recorded until February 5, 2021. RESULTS: Forty patients were included. Twenty-four patients (60%) were men; the median age was 53 (40-60) y old; median HT time was 34 mo; and median follow-up time 162 d. The majority needed hospitalization (83%). Immunosuppressive therapy was reduced/withdrawn in the majority of patients, except from steroids, which were maintained. Seventeen patients (42.5%) were classified as having severe disease according to the ordinal scale developed by the World Health Organization Committee. They tended to have lower absolute lymphocyte count (P < 0.001) during follow-up when compared with patients with mild disease. Thirty-day mortality was 12.5%. However, a longer follow-up revealed increased later mortality (27.5%), with median time to death around 35 d. Bacterial nosocomial infections were a leading cause of death. Cardiac allograft rejection (10%) and ventricular dysfunction (12.5%) were also not negligible. CONCLUSIONS: Major findings of this study corroborate other cohorts' results, but it also reports significant rate of later events, suggesting that a strict midterm surveillance is advisable to HT recipients with coronavirus disease 2019.
  • |*COVID-19[MESH]
  • |*Heart Transplantation/adverse effects[MESH]
  • |Adult[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Immunosuppression Therapy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2[MESH]


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