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10.1097/TP.0000000000003766

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33756547!8487704!33756547
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suck abstract from ncbi


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pmid33756547      Transplantation 2021 ; 105 (10): 2165-2169
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  • SARS-Cov-2 Seroprevalence in a French Kidney Transplant Center Located Within a "High-risk" Zone #MMPMID33756547
  • Caillard S; Benotmane I; Meidinger C; Jegou V; Ludwiller S; Rihon A; Desmarquets A; Steinmetz L; Morvan M; Kedjam K; Bigot A; Roy D; Schmitt D; Marx D; Bassand X; Perrin P; Gautier Vargas G; Cognard N; Olagne J; Braun L; Heibel F; Martzloff J; Moulin B; Fafi Kremer S
  • Transplantation 2021[Oct]; 105 (10): 2165-2169 PMID33756547show ga
  • BACKGROUND: Data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in kidney transplant recipients (KTRs) remain rare. We sought to shed further light on this issue by conducting a single-center study in a kidney transplant center located in one of the France's highest risk zone (Grand Est) for coronavirus disease 2019 (Covid-19) during the initial disease outbreak. METHODS: To this aim, we used a survey approach coupled with systematic investigation of SARS-CoV-2 serology in a cohort of 1390 KTRs. RESULTS: SARS-CoV-2 serologies were available for 780 survey respondents, among whom 48 had anti-SARS-CoV-2 antibodies (total seroprevalence: 6.2%). Thirty-five of the 48 seropositive KTRs had previously received a diagnosis of Covid-19, whereas the remaining 13 patients were not known to be infected (8 asymptomatic cases). Specifically, 18.7% of seropositive KTRs and 1.1% of the entire cohort were asymptomatic. Household exposure was found to markedly increase the risk of SARS-CoV-2 transmission. CONCLUSIONS: Our findings demonstrate that the overall SARS-CoV-2 seroprevalence in KTRs living in one of the France's highest risk zone for Covid-19 during the first French lockdown was as low as 6.3%. Rapid and strict implementation of protective measures could have significantly mitigated virus spread even in an area of high virus circulation.
  • |*Kidney Transplantation[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |France/epidemiology[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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