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10.1159/000514286 http://scihub22266oqcxt.onion/10.1159/000514286 33756482!ä!33756482 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33756482.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Kidney+Blood+Press+Res 2021 ; 46 (2): 152-161 Nephropedia Template TP {{tp|p=33756482|t=2021. Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease |pdf=|usr=}}{{33756482}} gab.com Text Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease JO: Kidney Blood Press Res http://www.kidney.de/pget.php?&tw=1&pmid=33756482 #FOAvip BACKGROUND: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. Availability is ensured by dietary intake of its precursors and by de novo production via sunlight. Yet, vitamin D deficiency and insufficiency are very common across the globe and are connected to many pathophysiological states, for example, diabetes mellitus, allergies, autoimmune diseases, pregnancy complications, and recently have also been associated with worse COVID-19 clinical outcomes. SUMMARY: In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. Key Messages: Vitamin D is not only a vitamin but also a hormone involved in many physiological processes. Its insufficiency or deficiency can lead to many pathological states. Twit Text FOAVip Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease ????Kidney Blood Press Res http://www.kidney.de/pget.php?&tw=1&pmid=33756482 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33756482 #FOAvip English Wikipedia <ref>{{Cite pmid|33756482}}</ref> Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease #MMPMID33756482 Galuska D; Pacal L; Kankova K Kidney Blood Press Res 2021[]; 46 (2): 152-161 PMID33756482show ga BACKGROUND: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. Availability is ensured by dietary intake of its precursors and by de novo production via sunlight. Yet, vitamin D deficiency and insufficiency are very common across the globe and are connected to many pathophysiological states, for example, diabetes mellitus, allergies, autoimmune diseases, pregnancy complications, and recently have also been associated with worse COVID-19 clinical outcomes. SUMMARY: In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. Key Messages: Vitamin D is not only a vitamin but also a hormone involved in many physiological processes. Its insufficiency or deficiency can lead to many pathological states. |Animals[MESH] |COVID-19/metabolism[MESH] |Diabetes Mellitus/drug therapy/etiology/*metabolism/physiopathology[MESH] |Diabetic Nephropathies/drug therapy/etiology/*metabolism/physiopathology[MESH] |Humans[MESH] |Signal Transduction/drug effects[MESH] |Vitamin D Deficiency/complications/drug therapy/*metabolism/physiopathology[MESH] |Vitamin D/*metabolism/therapeutic use[MESH]Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease(epmc).pdf DeepDyve Pubget Overpricing