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Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection #MMPMID33756475
Spagnolello O; Pinacchio C; Santinelli L; Vassalini P; Innocenti GP; De Girolamo G; Fabris S; Giovanetti M; Angeletti S; Russo A; Mastroianni CM; Ciccozzi M; Ceccarelli G; d'Ettorre G
Chemotherapy 2021[]; 66 (1-2): 24-32 PMID33756475show ga
Respiratory and gastrointestinal symptoms are the predominant clinical manifestations of the coronavirus disease 2019 (COVID-19). Infecting intestinal epithelial cells, the severe acute respiratory syndrome coronavirus-2 may impact on host's microbiota and gut inflammation. It is well established that an imbalanced intestinal microbiome can affect pulmonary function, modulating the host immune response ("gut-lung axis"). While effective vaccines and targeted drugs are being tested, alternative pathophysiology-based options to prevent and treat COVID-19 infection must be considered on top of the limited evidence-based therapy currently available. Addressing intestinal dysbiosis with a probiotic supplement may, therefore, be a sensible option to be evaluated, in addition to current best available medical treatments. Herein, we summed up pathophysiologic assumptions and current evidence regarding bacteriotherapy administration in preventing and treating COVID-19 pneumonia.