Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.intimp.2021.107567 http://scihub22266oqcxt.onion/10.1016/j.intimp.2021.107567 33756225!7945790!33756225     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33756225.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+Immunopharmacol 2021 ; 95 (ä): 107567 Nephropedia Template TP {{tp|p=33756225|t=2021. Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues |pdf=|usr=}}{{33756225}} gab.com Text Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33756225 #FOAvip Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. However, the mechanism of tissue tropism of SARS-CoV-2 remains unclear. Here, recombinant receptor-binding subdomain 1 of spike protein of SARS-CoV-2 (RBD-SD1) was used as a probe to investigate the potential tropism of SARS-CoV-2 in thirty-three types of normal human tissues. RBD-SD1 probe was observed to interact with cells in reported SARS-CoV-2 infected organs. Interestingly, the RBD-SD1 probe strongly interacted with bone marrow cells in an angiotensin-converting enzyme 2 (ACE2)-independent manner. In addition, SARS-CoV-2 induced the ACE2 mRNA expression in human primary bone marrow cells, suggesting human bone marrow cells may be sensitive to SARS-CoV-2 infection. Therefore, human bone marrow cells could be strongly infected by SARS-CoV-2, which may play an important role in the pathogenesis of COVID-19. These findings provide a deeper understanding of SARS-CoV-2 infection routes, thus contributing to the treatment of COVID-19. Twit Text FOAVip Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33756225 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33756225 #FOAvip English Wikipedia <ref>{{Cite pmid|33756225}}</ref> Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues #MMPMID33756225 Zheng B; Yuan M; Ma Q; Wang S; Tan Y; Xu Y; Ye J; Gao Y; Sun X; Yang Z; Xu P; Kong L; Wu X; Xu Q Int Immunopharmacol 2021[Jun]; 95 (ä): 107567 PMID33756225show ga Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. However, the mechanism of tissue tropism of SARS-CoV-2 remains unclear. Here, recombinant receptor-binding subdomain 1 of spike protein of SARS-CoV-2 (RBD-SD1) was used as a probe to investigate the potential tropism of SARS-CoV-2 in thirty-three types of normal human tissues. RBD-SD1 probe was observed to interact with cells in reported SARS-CoV-2 infected organs. Interestingly, the RBD-SD1 probe strongly interacted with bone marrow cells in an angiotensin-converting enzyme 2 (ACE2)-independent manner. In addition, SARS-CoV-2 induced the ACE2 mRNA expression in human primary bone marrow cells, suggesting human bone marrow cells may be sensitive to SARS-CoV-2 infection. Therefore, human bone marrow cells could be strongly infected by SARS-CoV-2, which may play an important role in the pathogenesis of COVID-19. These findings provide a deeper understanding of SARS-CoV-2 infection routes, thus contributing to the treatment of COVID-19. |Angiotensin-Converting Enzyme 2/biosynthesis/genetics[MESH] |Bone Marrow Cells/cytology/metabolism[MESH] |Humans[MESH] |Lung/cytology/metabolism[MESH] |Primary Cell Culture[MESH] |Protein Binding[MESH] |Protein Domains[MESH] |SARS-CoV-2/*chemistry/*metabolism[MESH] |Spike Glycoprotein, Coronavirus/*chemistry/*metabolism[MESH]Landscape of SARS-CoV-2 spike protein-interacting cells in human tissu(epmc).pdf DeepDyve Pubget Overpricing