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10.1016/j.intimp.2021.107567

http://scihub22266oqcxt.onion/10.1016/j.intimp.2021.107567
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suck abstract from ncbi


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pmid33756225      Int+Immunopharmacol 2021 ; 95 (ä): 107567
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  • Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues #MMPMID33756225
  • Zheng B; Yuan M; Ma Q; Wang S; Tan Y; Xu Y; Ye J; Gao Y; Sun X; Yang Z; Xu P; Kong L; Wu X; Xu Q
  • Int Immunopharmacol 2021[Jun]; 95 (ä): 107567 PMID33756225show ga
  • Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. However, the mechanism of tissue tropism of SARS-CoV-2 remains unclear. Here, recombinant receptor-binding subdomain 1 of spike protein of SARS-CoV-2 (RBD-SD1) was used as a probe to investigate the potential tropism of SARS-CoV-2 in thirty-three types of normal human tissues. RBD-SD1 probe was observed to interact with cells in reported SARS-CoV-2 infected organs. Interestingly, the RBD-SD1 probe strongly interacted with bone marrow cells in an angiotensin-converting enzyme 2 (ACE2)-independent manner. In addition, SARS-CoV-2 induced the ACE2 mRNA expression in human primary bone marrow cells, suggesting human bone marrow cells may be sensitive to SARS-CoV-2 infection. Therefore, human bone marrow cells could be strongly infected by SARS-CoV-2, which may play an important role in the pathogenesis of COVID-19. These findings provide a deeper understanding of SARS-CoV-2 infection routes, thus contributing to the treatment of COVID-19.
  • |Angiotensin-Converting Enzyme 2/biosynthesis/genetics[MESH]
  • |Bone Marrow Cells/cytology/metabolism[MESH]
  • |Humans[MESH]
  • |Lung/cytology/metabolism[MESH]
  • |Primary Cell Culture[MESH]
  • |Protein Binding[MESH]
  • |Protein Domains[MESH]
  • |SARS-CoV-2/*chemistry/*metabolism[MESH]
  • |Spike Glycoprotein, Coronavirus/*chemistry/*metabolism[MESH]


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