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10.1002/jmv.26954

http://scihub22266oqcxt.onion/10.1002/jmv.26954
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33755218!8251493!33755218
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suck abstract from ncbi


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pmid33755218      J+Med+Virol 2021 ; 93 (7): 4370-4373
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  • Use of chlorhexidine to eradicate oropharyngeal SARS-CoV-2 in COVID-19 patients #MMPMID33755218
  • Huang YH; Huang JT
  • J Med Virol 2021[Jul]; 93 (7): 4370-4373 PMID33755218show ga
  • As public distribution of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is underway, prevention of coronavirus disease 2019 (COVID-19) relies on minimizing spread. In this study, chlorhexidine gluconate was investigated as a topical antimicrobial agent against SARS-CoV-2. This was a randomized, prospective cohort study using chlorhexidine as an oral rinse and posterior oropharyngeal spray in hospitalized COVID-19 patients. The primary outcome was presence or absence of laboratory-confirmed SARS-CoV-2 in the oral and oropharyngeal cavities after 4 days of chlorhexidine use and standard of care (study group) or standard of care only (control group). SARS-CoV-2 was eliminated from the oropharynx in 62.1% of patients who used chlorhexidine as an oral rinse, versus 5.5% of the control group patients. Among patients who used a combination of oral rinse and oropharyngeal spray, 86.0% eliminated oropharyngeal SARS-CoV-2, versus 6.3% of control patients. Chlorhexidine is a simple and safe addition to current COVID-19 prevention guidelines and may play a significant role in reducing disease spread.
  • |*COVID-19 Drug Treatment[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |COVID-19/prevention & control[MESH]
  • |Chlorhexidine/*analogs & derivatives/therapeutic use[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mouthwashes/*therapeutic use[MESH]
  • |Prospective Studies[MESH]
  • |SARS-CoV-2/*drug effects[MESH]


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