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Increased SARS-CoV-2 Testing Capacity with Pooled Saliva Samples #MMPMID33755009
Watkins AE; Fenichel EP; Weinberger DM; Vogels CBF; Brackney DE; Casanovas-Massana A; Campbell M; Fournier J; Bermejo S; Datta R; Dela Cruz CS; Farhadian SF; Iwasaki A; Ko AI; Grubaugh ND; Wyllie AL
Emerg Infect Dis 2021[Apr]; 27 (4): 1184-7 PMID33755009show ga
We analyzed feasibility of pooling saliva samples for severe acute respiratory syndrome coronavirus 2 testing and found that sensitivity decreased according to pool size: 5 samples/pool, 7.4% reduction; 10 samples/pool, 11.1%; and 20 samples/pool, 14.8%. When virus prevalence is >2.6%, pools of 5 require fewer tests; when <0.6%, pools of 20 support screening strategies.