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10.1016/j.nano.2021.102388 http://scihub22266oqcxt.onion/10.1016/j.nano.2021.102388 33753282!7979277!33753282     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nanomedicine 2021 ; 34 (ä): 102388 Nephropedia Template TP {{tp|p=33753282|t=2021. Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury |pdf=|usr=}}{{33753282}} gab.com Text Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury JO: Nanomedicine http://www.kidney.de/pget.php?&tw=1&pmid=33753282 #FOAvip Acute respiratory distress syndrome (ARDS) is a devastating pulmonary disease with significant in-hospital mortality and is the leading cause of death in COVID-19 patients. Excessive leukocyte recruitment, unregulated inflammation, and resultant fibrosis contribute to poor ARDS outcomes. Nanoparticle technology with cerium oxide nanoparticles (CNP) offers a mechanism by which unstable therapeutics such as the anti-inflammatory microRNA-146a can be locally delivered to the injured lung without systemic uptake. In this study, we evaluated the potential of the radical scavenging CNP conjugated to microRNA-146a (termed CNP-miR146a) in preventing acute lung injury (ALI) following exposure to bleomycin. We have found that intratracheal delivery of CNP-miR146a increases pulmonary levels of miR146a without systemic increases, and prevents ALI by altering leukocyte recruitment, reducing inflammation and oxidative stress, and decreasing collagen deposition, ultimately improving pulmonary biomechanics. Twit Text FOAVip Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury ????Nanomedicine http://www.kidney.de/pget.php?&tw=1&pmid=33753282 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33753282 #FOAvip English Wikipedia <ref>{{Cite pmid|33753282}}</ref> Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury #MMPMID33753282 Niemiec SM; Hilton SA; Wallbank A; Azeltine M; Louiselle AE; Elajaili H; Allawzi A; Xu J; Mattson C; Dewberry LC; Hu J; Singh S; Sakthivel TS; Sea S; Nozik-Grayck E; Smith B; Zgheib C; Liechty KW Nanomedicine 2021[Jun]; 34 (ä): 102388 PMID33753282show ga Acute respiratory distress syndrome (ARDS) is a devastating pulmonary disease with significant in-hospital mortality and is the leading cause of death in COVID-19 patients. Excessive leukocyte recruitment, unregulated inflammation, and resultant fibrosis contribute to poor ARDS outcomes. Nanoparticle technology with cerium oxide nanoparticles (CNP) offers a mechanism by which unstable therapeutics such as the anti-inflammatory microRNA-146a can be locally delivered to the injured lung without systemic uptake. In this study, we evaluated the potential of the radical scavenging CNP conjugated to microRNA-146a (termed CNP-miR146a) in preventing acute lung injury (ALI) following exposure to bleomycin. We have found that intratracheal delivery of CNP-miR146a increases pulmonary levels of miR146a without systemic increases, and prevents ALI by altering leukocyte recruitment, reducing inflammation and oxidative stress, and decreasing collagen deposition, ultimately improving pulmonary biomechanics. |*Cerium/chemistry/pharmacology[MESH] |*Drug Delivery Systems[MESH] |*MicroRNAs/chemistry/pharmacology[MESH] |Animals[MESH] |Bleomycin/*adverse effects/pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/genetics/metabolism[MESH] |Disease Models, Animal[MESH] |Male[MESH] |Mice[MESH] |Respiratory Distress Syndrome/chemically induced/*drug therapy/genetics/metabolism[MESH]Cerium oxide nanoparticle delivery of microRNA-146a for local treatmen(epmc).pdf DeepDyve Pubget Overpricing