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10.1016/j.micinf.2021.104808

http://scihub22266oqcxt.onion/10.1016/j.micinf.2021.104808
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33753206!7979272!33753206
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suck abstract from ncbi


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pmid33753206      Microbes+Infect 2021 ; 23 (4-5): 104808
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  • Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering #MMPMID33753206
  • Farina A; Labriola R; Ialongo C; Suppa M; Viggiani V; Lucarelli M; Anastasi E; Angeloni A
  • Microbes Infect 2021[May]; 23 (4-5): 104808 PMID33753206show ga
  • An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.
  • |Aged[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |COVID-19/*complications/immunology[MESH]
  • |Coronavirus Nucleocapsid Proteins/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interleukin-6/*immunology[MESH]
  • |Italy[MESH]
  • |Male[MESH]
  • |Paraproteinemias/immunology/*virology[MESH]
  • |Phosphoproteins/immunology[MESH]


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