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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Microbes+Infect 2021 ; 23 (4-5): 104808 Nephropedia Template TP
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Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering #MMPMID33753206
Farina A; Labriola R; Ialongo C; Suppa M; Viggiani V; Lucarelli M; Anastasi E; Angeloni A
Microbes Infect 2021[May]; 23 (4-5): 104808 PMID33753206show ga
An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.